Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas

Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas : Molecular Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinoma

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Description

Classical histology has been augmented by
immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system.

This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method.
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Product details

  • Hardback | 608 pages
  • 218.4 x 281.9 x 30.5mm | 2,063.87g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Approx. 150 illustrations (50 in full color); Illustrations, unspecified
  • 0123694027
  • 9780123694027

Review quote

"The basics of cell biology and molecular biology precede each section that describes defects in genetic/epigenetic control. Gaining an understanding of molecular genetic defects in cancer, authors then proceed to tell you how to measure the defects, which reinforces your understanding of the basic pathobiologic process. The latest therapies are discussed in the context of how to repair these molecular defects. Timely chapters on specific molecular topics in ovarian and gastrointestinal tumors are presented in the format of formal research papers. Extremely well written and succinct, a perfect marriage of information for students at any level, from medical student to professors of oncology."
-- David J. Dabbs, M.D., Chief of Pathology, Magee Women's Hospital University of Pittsburgh School of Medicine
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About M. A. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.
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Table of contents

Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas

Front Matter

Dedication

Authors and Coauthors of Volume 4

Foreword

Preface

Selected Definitions

Classification Scheme of Human Cancers

Identification of Tumor-Specific Genes

The Post-Translational Phase of Gene Expression in Tumor Diagnosis

Role of Tumor Suppressor BARD1 in Apoptosis and Cancer

Angiogenesis, Metastasis, and Epigenetics in Cancer

Can Effector Cells Really aEURO÷EffectaEURO an Anti-Tumor Response as Cancer Therapy?

Circulating Cancer Cells

Circulating Cancer Cells: Flow Cytometry, Video Microscopy, and Confocal Laser Scanning Microscopy

Gastrointestinal Carcinoma: An Introduction

Role of Immunohistochemical Expression of p53 in Gastric Carcinoma

Role of Immunohistochemical Expression of p53 and Vascular Endothelial Growth Factor in Gastric Carcinoma

Role of Immunohistochemical Expression of p150 in Gastric Carcinoma: The Association with p53, Apoptosis, and Cell Proliferation

Role of Immunohistochemical Expression of Ki-67 in Adenocarcinoma of Large Intestine

Role of Immunohistochemical Expression of KIT/CD117 in Gastrointestinal Stromal Tumors

Role of Immunohistochemical Expression of BUB1 Protein in Gastric Cancer

Role of Immunohistochemical Expression of Epidermal Growth Factor in Gastric Tumors

Role of Immunohistochemical Expression of Beta-Catenin and Mucin in Stomach Cancer

Loss of Cyclin D2 Expression in Gastric Cancer

Role of Immunohistochemical Expression of E-Cadherin in Diffuse-Type Gastric Cancer

Role of Immunohistochemical Expression of Adenomatous Polyposis Coli and E-Cadherin in Gastric Carcinoma

Immunohistochemical Expression of Chromogranin A and Leu-7 in Gastrointestinal Carcinoids

Role of Immunohistochemical Expression of MUC5B in Gastric Carcinoma

Angiogenin in Gastric Cancer and Its Roles in Malignancy

Role of Helicobacter pylori in Gastric Cancer

Protein Alterations in Gastric Adenocarcinoma

Vesicle Proteins in Neuroendocrine and Nonendocrine Tumors of the Gastrointestinal Tract

Role of Immunohistochemical Expression of Caspase-3 in Gastric Carcinoma

Role of Immunohistochemical Expression of PRL-3 Phosphatase in Gastric Carcinoma

Role of Immunohistochemical Expression of DNA Methyltransferase 1 Protein in Gastric Carcinoma

Role of Immunohistochemical Expression of Cytoplasmic Trefoil Factor Family-2 in Gastric Cancer

Role of Immunohistochemical Expression of Cytokeratins in Small Intestinal Adenocarcinoma

Quantitative Immunohistochemistry by Determining the Norm of the Image Data File

Ovarian Carcinoma: An Introduction

Methods for Detecting Genetic Abnormalities in Ovarian Carcinoma Using Fluorescence in situ Hybridization and Immunohistochemistry

Role of Immunohistochemical Expression of HER2/neu in High-Grade Ovarian Serous Papillary Cancer

Role of Immunohistochemical Expression of BRCA1 in Ovarian Carcinoma

Role of BRCA1/BRCA2 in Ovarian, Fallopian Tube, and Peritoneal Papillary Serous Carcinoma

K-Ras Mutations in Serous Borderline Tumors of the Ovary

Role of Immunohistochemical Expression of Ki-67 in Ovarian Carcinoma

Role of Expression of Estrogen Receptor I(2), Proliferating Cell Nuclear Antigen, and p53 in Ovarian Granulosa Cell Tumors

Role of Immunohistochemical Expression of Cyclooxygenase-2 in Ovarian Serous Carcinoma

Role of Immunohistochemical Expression of Cyclooxygenase and Peroxisome ProliferatoraEURO"Activated Receptor I(3) in Epithelial Ovarian Tumors

CDX2 Immunostaining in Primary and Secondary Ovarian Carcinomas

Epithelial Ovarian Cancer and the E-CadherinaEURO"Catenin Complex

Role of Cytokeratin Immunohistochemistry in the Differential Diagnosis of Ovarian Tumors

Role of Immunohistochemical Expression of Cytokeratins and Mucins in Ampullary Carcinomas

Role of Integrins in Ovarian Cancer

Role of Immunohistochemical Expression of Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor Receptor 2 in Ovarian Cancer

Use of Microarray in Immunohistochemical Localization of SMAD in Ovarian Carcinoma

Role of Immunohistochemical Expression of Fas in Ovarian Carcinoma

Role of Immunohistochemical Expression of Lewis Y Antigen in Ovarian Carcinoma

Role of Immunohistochemical Expression of ETS-1 Factor in Ovarian Carcinoma

Role of MCL-1 in Ovarian Carcinoma

Role of Elf-1 in Epithelial Ovarian Carcinoma: Immunohistochemistry

Role of Immunohistochemical Expression of OCT4 in Ovarian Dysgerminoma

Immunohistochemical Validation of B7-H4 (DD-O110) as a Biomarker of Ovarian Cancer: Correlation with CA-125

Role of Immunohistochemical Expression of Alpha Glutathione S-Transferase in Ovarian Carcinoma

Role of Immunohistochemical Expression of Aminopeptidases in Ovarian Carcinoma

Expression of Angiopoietin-1, Angiopoietin-2, and Tie2 in Normal Ovary with Corpus Luteum and in Ovarian Carcinoma

The Role of Immunohistochemical Expression of 1,25-Dihydroxyvitamin-D3-Receptors in Ovarian Carcinoma

Role of Immunohistochemical Expression of Antigens in Neuroendocrine Carcinoma of the Ovary and Its Differential Diagnostic Considerations

Role of Immunohistochemistry in Elucidating Lung Cancer Metastatic to the Ovary from Primary Ovarian Carcinoma

Index
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