Handbook of Drug Screening

Handbook of Drug Screening

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Description

Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery.





With extensively updated content and 21 new chapters, this text examines:















quality and efficiency of drug target validation and potential drug compound selection
reducing assay costs and improvement in assay technology
data quality improvement
trends in drug discovery
how drug screening can minimize adverse drug effects
recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry
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Product details

  • Hardback | 504 pages
  • 152 x 229 x 33.02mm | 794g
  • CRC Press Inc
  • Bosa Roca, United States
  • English
  • New edition
  • 2nd New edition
  • 100 Illustrations, black and white
  • 1420061682
  • 9781420061680
  • 2,023,654

Table of contents

Key Factors for Successful High-Throughput Screening, John G. Houston
Critical Components in High-Throughput Screening: Challenges and New Trends, Litao Zhang, Martyn N. Banks, and John G. Houston
Hit-to-Probe-to-Lead Optimization Strategies: A Biology Perspective to Conquer the Valley of Death, Anuradha Roy, Byron Taylor, Peter R. McDonald, Ashleigh Price, and Rathnam Chaguturu
Signal Detection Platforms for Screening in Drug Discovery, Ramakrishna Seethala
Proteomic Analysis in Drug Discovery, Haiteng Deng, Yang Xu, and Linqi Zhang
Screening and Characterization of G-Protein-Coupled Receptor Ligands for Drug Discovery, Ge Zhang and Mary Ellen Cvijic
Nuclear Hormone Receptor Screening in Drug Discovery, Ramakrishna Seethala and Litao Zhang
Emerging Novel High-Throughput Screening Technologies for Cell-Based Assays, Ilona Kariv, Alexander A. Szewczak, Nathan W. Bays, Nadya Smotrov, and Christopher M. Moxham
In Vitro Strategies for Ion Channel Screening in Drug Discovery, Ravikumar Peri, Mark Bowlby, and John Dunlop
Wheat from Chaff: General andMechanistic Triage of Screening Hits for Enzyme Targets, Mark R. Harpel
Protein Kinases and Phosphatases, Pirthipal Singh
MicroRNA Strategies in Drug Discovery, Wishva B. Herath, Dwi S. Karolina, Arunmozhiarasi Armugam, and Kandiah Jeyaseelan
Strategies for Screening of Biologic Therapeutics, Ian Foltz and Francesca Civoli
Cryopreserved Cells in Functional Cell-Based HTS Assays, Geetha Shankar and Kirk McMillan
High-Content Screening with a Special Emphasis on Cytotoxicity and Cell Health Measurementsn Ralph J. Garippa and Ann F. Hoffman
Effective Application of DrugMetabolism and Pharmacokinetics in Drug Discovery, Sharon Diamond and Swamy Yeleswaram
Compound Management for Drug Discovery: An Overview, Moneesh Chatterjee and Martyn N. Banks
Practical Approach to Quantitative High Throughput Screening, Wei Zheng, Ke Liu, and James Inglese
Enabling the Large-Scale Analysis of Quantitative High-Throughput Screening Data, Noel T. Southall, Ajit Jadhav, Ruili Huang, Trung Nguyen, and Yuhong Wang
Application of Nanobiotechnologies for Drug Discovery, K. K. Jain
Index
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