Handbook of the Biology of Aging

Handbook of the Biology of Aging

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Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of `big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.

The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.
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Product details

  • Paperback | 576 pages
  • 191 x 235 x 25.4mm | 1,160g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 8th edition
  • 0124115969
  • 9780124115965
  • 1,530,037

Table of contents

Foreword Preface

Section I: Basic Mechanisms of Aging: Models and Systems

Chapter 1 - Longevity as a Complex Genetic Trait George L. Sutphin and Ron Korstanje

Chapter 2 - The mTOR Pathway and Aging Katherine H. Schreiber, Monique N. O'Leary, and Brian K. Kennedy

Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals William Giblin and David B. Lombard

Chapter 4 - The Hypoxic Response and Aging Scott F. Leiser, Hillary A. Miller, and Matt Kaeberlein

Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging Michael J. Waterson and Scott D. Pletcher

Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan Kaitlyn N. Lewis and Rochelle Buffenstein

Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease Ting-Lin B. Yang, Shufei Song, and F. Brad Johnson

Chapter 8 - Systems Approaches to Understanding Aging Lei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. Han

Chapter 9 - Integrative Genomics of Aging Joao Pedro de Magalhaes and Robi Tacutu

Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E. Harrison

Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species Michael Van Meter, Vera Gorbunova, and Andrei Seluanov

Section II: The Pathobiology of Human Aging

Chapter 12 - Genetics of Human Aging Miook Cho and Yousin Suh

Chapter 13 - The Aging Arterial Wall Mingyi Wang, Robert E. Monticone, and Edward G. Lakatta

Chapter 14 - Age-Related Alterations in Neural Plasticity Shannon J. Moore and Geoffrey G. Murphy

Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention Ludmila Muller and Graham Pawelec

Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms Ingrid A. Harten, Michelle Olive, and Thomas N. Wight

Chapter 17 - Cardiac Aging Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. Rabinovitch

Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity Eileen M. Cr4immins and Morgan E. Levine

Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond James F. Fries
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About Matt Kaeberlein

Matt Kaeberlein is a Professor of Pathology and Adjunct Professor of Genome Sciences at the University of Washington. He is the co-Director of the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging and Director of the Healthy Aging and Longevity Research Institute. His activities related to the biology of aging have included serving on the Executive Committee of the Biological Sciences section of the Gerontological Society of America and the Board of Directors for the American Aging Association. Dr. Kaeberlein also Directed the Biology of Aging Summer Course and the Marine Biological Laboratory in Woods Hole, MA from 2014-2015. Dr. Kaeberlein has authored more than 130 publications on the basic biology of aging, and has been recognized with several awards, including a Breakthroughs in Gerontology Award from the Glenn Foundation, an Alzheimer's Association Young Investigator Award, an Ellison Medical Foundation New Scholar in Aging Award, an Undergraduate Research Mentor of the Year Award, and a Murdock Trust Award. In 2011, he was named the Vincent Cristofalo Rising Star in Aging Research by the American Federation for Aging Research and appointed as a Fellow of the Gerontological Society of America, and in 2014 he was elected as the incoming President of the American Aging Association. Dr. Kaeberlein currently serves on the editorial boards for Science, Aging Cell, Cell Cycle, PloS One, Frontiers in Genetics of Aging, npj Aging and Mechanisms of Disease, F1000 Research, Ageing Research Reviews, BioEssays, and Oncotarget George Martin is Professor Emeritus of Pathology (Active) at the University of Washington, where he has also served as an Adjunct Professor of Genome Sciences. He was the Founding Director of that institution's Medical Scientist Training Program, Alzheimer's Disease Research Center and the first NIA T32 training grant on genetic approaches to aging research. His activities related to the biology of aging have included the Presidency of the Gerontological Society of America, the Scientific Directorship and Presidency of the American Federation for Aging Research, membership on the National Advisory Council and Board of Scientific Counselors of the National Institute on Aging, member and Chair of the Scientific Advisory Board of the Ellison Medical Foundation and Chairmanship of a Gordon Conference on the Biology of Aging. Honors for his research have included the Brookdale, Kleemeier and Paul Glenn Foundation awards of the Gerontological Society of America, the Allied-Signal Corporation Award, the Irving Wright Award of the American Federation for Aging Research, the American Aging Association Research Medal and Distinguished Scientist Award, the Pruzanski Award of the American College of Medical Genetics, and a World Alzheimer Congress Lifetime Achievement Award. He has also received an Outstanding Alumnus Award from the University of Washington School of Medicine. Dr. Martin was elected to the Institute of Medicine of the National Academy of Sciences and now serves as a Senior Member. Dr. Martin's research focus has been on genetic aspects of aging in mammals, particularly human subjects. That research led to the characterizations of mutations responsible for several segmental progeroid syndromes, notably the Werner syndrome, as well as early studies of the genetics of dementias of the Alzheimer type.
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