A Guide to Polyamines

A Guide to Polyamines

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Polyamines are ubiquitous and essential organic cations in prokaryotic and eukaryotic cells. This text is a comprehensive survey of the development of knowledge of their physiological and structural roles. The genetic and regulatory determinants of the amines and their cellular composition are actively explored as parameters of normal physiology and aberrant pathologies. Cancer, virus infection, and protozoan parasitism are major examples of the latter group. Studies of the control of polyamine metabolism are providing important therapeutic leads. Further, the structural roles of the amines are being determined at molecular levels, contributing to the understanding of polynucleotide and protein organization and interaction, as well as to the solution of problems of genome transfer. These subjects describe a burgeoning biochemical area involving compounds whose roles in cytoplasmic and nuclear function include numerous aspects of organelle structure, polymer synthesis, and interactions.
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Product details

  • Hardback | 610 pages
  • 180 x 258 x 34mm | 1,401.59g
  • New York, United States
  • English
  • 161 line drawings, bibliography
  • 0195110641
  • 9780195110647

Table of contents

Preface. 1: Historical Introduction, with Time Line. 2: Structures and Synthesis of the Polyamines. 3: Some Properties of the Polyamines and Their Analysis. 4: Macrocyclic Polyamines - A Digression?. 5: The Free Polyamines and Their Distribution. 6: Polyamine Oxidases and Dehydrogenases. 7: Bacterial Metabolism and the Pollyamines. 8: The Biosynthesis and Metabolism of the Diamines in Bacteria. 9: Spermidine and Other Bacterial Polyamines. 10: Model Eukaryotic Systems: Some Fungi, Slime Molds. 11: Polyamines and the Animal Cell. 12: The Pathways of Polyamine Metabolism in Animal Cells. 13: Biosynthetic Enzymes of Animal Tissue and Cells: The Properties and Regulation of Ornithine Decarboxylase. 14: The Mammalian Biosynthetic Enzymes (Part II). 15: Cancer: On the Biochemistry of Carcinogenesis Initiation. 16: Polyamine Metabolism and the Promotion of Tumor Growth. 17: Cancers - Controlling the Disease. 18: Mostly Protozoans - Some Third World Parasites. 19: The Viruses. 20: Plant Metabolism. 21: Molecular Reactions at Cell Surfaces. 22: Molecular Reactions with Intracellular Polymers A. 23: Molecular Reactions with Intracellular Polymers B: Transfer RNA and DNA
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