Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

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Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management.

This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment.
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Product details

  • Hardback | 368 pages
  • 154.94 x 231.14 x 30.48mm | 612.35g
  • United States
  • English
  • 0123878195
  • 9780123878199

Table of contents

Convergence of growth factor signalling pathways in developmental systems and pathogenesis
Growth factor families
TGF-ss family growth factors in differentiation and morphogenesis
Vascular endothelial growth factor
The hepatocyte growth Factor
The platelet derived growth factor family
Nerve Growth Factors
Insulin-like growth factors
Connective tissue growth factor (CTGF)
Growth factor and hedgehog signalling pathways meet in developmental systems
Epidermal Growth Factors and their signalling systems
Growth factors of the EGF family
The fibroblast growth factor family
Intracellular receptor binding growth factors
Androgens and androgen receptors (AR) in development, differentiation and neoplasia
Vitamin D3 in cell proliferation, apoptosis and differentiation
Retinoids in development and pattern formation
Oestrogens and progesterone in normal physiology and neoplasia
Glucocorticoid signalling in normal and aberrant physiology
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