Glycochemistry : Principles: Synthesis, and Applications

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US, Canadian, and Chinese chemists summarize recent research into the synthesis, principles, and applications of carbohydrates for graduate students and researchers in carbohydrate chemistry, biochemistry, medicinal chemistry, and glycobiology. The topics include solid phase oligosaccharide synthesis, the chemical synthesis of bioactive steroidal saponins, the chemistry and biology of multi-valent saccharide displays, structures and mechanisms of action of aminoglycoside antibiotics, synthesizing glycosaminoglycans, glycosyltransferases in oligosaccharide synthesis, and metabolic substrate engineering as a tool for glycobiology Glycochemistry: Principles, Synthesis, and Applications presents methods used in the development of carbohydrate-based therapeutics. It highlights applications in chemical and enzymatic synthesis of complex carbohydrates, carbohydrate function, and carbohydrate-mediated biological recognition processes. There are practical examples on the development of carbohydrate-based pharmaceuticals and polymers for commercial use. The text also emphasizes the role of carbohydrates as key elements in modern molecular recognition processes.
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Product details

  • Hardback | 696 pages
  • 216 x 279 x 36.83mm | 1,451g
  • CRC Press Inc
  • Bosa Roca, United States
  • English
  • 0824705386
  • 9780824705381

Table of contents

Introduction - New Challenges in Carbohydrate Research
Solid Phase Oligosaccharide Synthesis
Dehydrative Glycosylation with 1-Hydroxy Donors
Chemistry of Clycosyl Triflates - Synthesis of Beta-Mannopyranosides
C-Glycoside Synthesis - Recent Developments and Current Trends
D-Arabinofuranosides from Mycobacteria - Synthesis and Conformation
Chemical Synthesis of Bioactive Steroidal Saponins
Recent Developments in Technology for Clycosylation with Sialic Acid
The Chemistry and Biology of Multivalent Saccharide Displays
designing Novel Multivalent Blycotools for Biochemical Investigations Related to Sialic Acid
Aminoglycoside Antibiotics - Structures and Mechanisms of Action
Methodologies in Syntheses of Aminoglycoside Antibiotics
Synthesis of Glycoaminoglycans
Pyranosyl Sugar Amino Acid Conjugates - Their Biological Origins, Synthetic Preparations, and Structural Characterization
Glycosyltransferases in Oligosaccharide Synthesis
Biotransformation of Polysaccharides
From a Carbohydrate Sequence to Extensive Research Programmes - A Case Study
Microbial Glycosyltransferases
Metabolic Substrate Engineering as a Tool for Glycobiology
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Review quote

"provides a fresh perspectivewell-referencedshows the enormous diversity of contemporary glycochemistry." - Journal of the American Chemical Society
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