Global Strategies for Disease Detection and Treatment : Proteomics
The field of proteomics holds great promise for identifying non-targeted, global molecular profiles "signatures" of normal and diseased cells. While genomics offers an array of tools for identifying mutated or dysregulated genes, proteonomics offers the ability to measure post-translational modifications, protein stability, phosphorylation state, protein-protein interactions, and protein DNA-binding affinities. This work shows that strategies based on the separate analysis of subcellular compartments provide the means to determine protein location in a cell. Selective enrichment for a subset of proteins of interest can be achieved using a variety of techniques from centrifugation procedures to affinity capture.
- Paperback | 314 pages
- 188 x 259.1 x 7.6mm | 362.88g
- 01 Dec 2002
- IOS Press
- IOS Press,US
- Amsterdam, United States