GERD : Reflux to Esophageal Adenocarcinoma

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GERD: Reflux to Esophageal Adenocarcinoma, Second Edition, brings together a vast amount of disparate literature on the topic, presenting the entire pathogenesis of reflux disease in one convenient location. With gastroesophageal reflux disease now one of the most common maladies in humans, the text is a timely, informational compilation of data on how gastroesophageal reflux causes cellular changes in the esophagus.

The text also offers a complete solution to a problem that has confused physicians for over a century. Both clinical and pathological information regarding reflux disease and its treatment are presented, providing a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike.
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Product details

  • Hardback | 512 pages
  • 211 x 276mm
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • 0123945941
  • 9780123945945

About Parakrama T. Chandrasoma

Dr. Parakrama Chandrasoma was born in Sri Lanka and received his medical education and initial pathology training in the Medical School of the University of Sri Lanka. He has postgraduate degrees in internal medicine, including the M.D. (Sri Lanka) and Membership of the Royal College of Physicians (UK). He immigrated to the United States in 1978. Upon completing his pathology residency, he assumed duties as Chief of Surgical Pathology at the Los Angeles County + University of Southern California Medical Center He has held this position since. After an initial interest in neuropathology, Dr. Chandrasoma joined Dr. Tom DeMeester's Foregut Surgery team as pathologist in 1991. This led to a productive study of gastroesophageal reflux disease spanning 16 years and resulting in the development of numerous original concepts relating to the pathogenesis of gastroesophageal reflux disease. Dr. Chandrasoma has written over 140 peer reviewed papers and 6 previous pathology textbooks, including a general text on Gastrointestinal Pathology and a text on Gastroesophageal Reflux Disease, and is a Professor of Pathology at the Keck School of Medicine at the University of Southern California. He is married with three children and lives in Pasadena, California. Professor of Clinical Surgery and Chair of the Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
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Review quote

"An essential reading for whoever treats patients with gastroesophageal reflux disease, from gastroenterologists to surgeons."
--Marco G. Patti, MD, Professor of Surgery, University of California, San Francisco

"All of us who are involved in the care of patients with esophageal adenocarcinoma owe a debt of gratitude to Drs. DeMeester and Chandrasoma for producing the exceptional material contained within this text."
--Donald O. Castell, MD, Professor of Medicine, Director, Esophageal Disorders Program, Medical University of South Carolina

"This timely and authoritative book was written by two masters in the field whose experience spans two decades and includes supervision of studies involving more than 10,000 patients. The book is well written and demonstrates the advantages of having a limited number of authors and a narrow focus - namely, consistency of style and a cohesive philosophy...We therefore feel that this book is essential reading for anyone with an interest in esophageal disease, and particularly in GERD and esophageal adenocarcinoma."
-- The New England Journal of Medicine

"This book is extremely well written, carefully and thoughtfully prepared, and offers the open-minded reader a view of GERD that they would not read in any standard textbook or review article on the subject. The rich descriptions of the histopathology, views on carditis, cardiac intestinal metaplasia; and the microscopic definition of the gastroesophageal junction are valuable to all that study this disease." - Philp O. Katz, Thomas Jefferson University and Albert Einstein Medical Center, Philadelphia, PA, Gastroenterology, 2007

"This book describes a novel, fascinating, straight-forward approach towards understanding and management of gastroesophageal reflux disease(GERD), a disease that is `all about us'. The book is highly recommended to those who want to become better in the management of their patients with gastroesophageal reflux disease." - Johannes Lenglinger and Martin Riegler, European Surgery, 2007.

"We therefore feel that this book is essential reading for anyone with an interest in esophageal disease, and particularly in GERD and esophageal adenocarcinoma" - Subhas Banerjee and Jacques Van Dam, Stanford University School of Medicine, 2007
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Table of contents

Chapter 1: The history of Barrett's esophagus
Chapter 2: The Importance of Gastroesophageal Reflux
Chapter 3: Clinical Manifestations of Reflux Disease
Chapter 4: Definitions
Chapter 5: Development of Esophagus and Stomach and Cell Kinetics
Chapter 6: Normal Anatomy and Physiology of the Esophagus
Chapter 7: Gastricization - end-stage esophagus
Chapter 8: The lower esophageal sphincter and reflux
Chapter 9: Gastroesophageal Reflux and early changes in squamous epithelium
Chapter 10: Columnar transformation of the esophagus - Reflux carditis
Chapter 11: Evolution of Cardiac mucosa
Chapter 12. Injurious elements in the gastric refluxate
Chapter 13. Oxynto-cardiac mucosa: the Parietal cell
Chapter 14. Intestinal Metaplasia
Chapter 15: Intestinal Metaplasia of the Gastric Cardia
Chapter 16: Treatment of Reflux Disease
Chapter 17: Effect of Treatment on metaplastic columnar epithelium
Chapter 18: The Neoplastic transformation of intestinal metaplasia
Chapter 19: Adenocarcinoma induced by Reflux
Chapter 20: Treatment of adenocarcinoma of the Esophagus
Chapter 21: Pathologic assessment of the resected specimens
Chapter 22: The Future
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