Genomics, Proteomics, and Clinical Bacteriology

Genomics, Proteomics, and Clinical Bacteriology : Methods and Reviews

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Gazing into crystal balls is beyond the expertise of most scientists. Yet, as we look further into the 21st century, one does not have to be Nostradamus to predict that the current genomics and proteomics "revolution" will have an immense impact on medical bacteriology. This impact is already being re- ized in many academic departments, and although encroachment on routine diagnostic bacteriology, particularly in the hospital setting, is likely to occur at a slower pace, it remains nonetheless inevitable. Therefore, it is important that no one working in bacteriology should find themselves distanced from these fundamental developments. The involvement of all clinical bacteriologists is essential if the significant achievements of genome sequencing and analysis are to be turned into tangible advances, with resulting benefits for patient care and m- agement. It is our hope that Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews will play a part in bringing such a development to fruition. The advances in genomics and proteomics have already given us frequent opportunities to reassess our knowledge and understanding of established b- terial adversaries, and have provided us with the means to identify new foes. The new knowledge gained is enabling us to reconsider, for example, our c- cepts of bacterial pathogenicity, phylogeny and novel targets for antibacterial chemotherapy. These topics, and others, are considered in Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews.
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Product details

  • Hardback | 398 pages
  • 156 x 228 x 28mm | 798.34g
  • Totowa, NJ, United States
  • English
  • 2004 ed.
  • X, 398 p.
  • 1588292185
  • 9781588292186

Back cover copy

It is essential that all clinical bacteriologists become active participants in the current genomics and proteomics revolution if the significant achievements of genome sequencing and analysis are to produce real benefits for patient care. In Genomics, Proteomics, and Clinical Bacteriology, a panel of internationally renowned experts reviews how genomics has provided novel methods for bacterial investigation and advanced our knowledge of bacterial pathogenicity. The authors critically evaluate the applications of genomics to diagnostic bacteriology, highlighting both current and likely future uses, describing real-time PCR methods, and outlining the promise of microarrays in clinical bacteriology. Their discussion examines in detail genomic approaches to antibacterial discovery, the nature of pathogenicity, the discovery of new pathogens, the exploration of the concept of clonality in bacteria, and bacterial taxonomics. Introductory material explains for the uninitiated the relevance of genomics to the clinical laboratory, illustrating the art and science of working with public databases, digging for data, and exploiting bacterial proteomes.
Comprehensive and insightful, Genomics, Proteomics, and Clinical Bacteriology offers everyone working in medical bacteriology an accessible introduction to a rapidly evolving discipline, one that shows not only how knowledge of bacterial genome sequences affects diagnostic bacteriology today, but also how that knowledge may be used in the future to gain new insights into bacterial disease processes, identify critical targets for antiinfectives, and aid in designing novel antibiotics.
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Table of contents

Part I. Principles of Bacterial Genomics

Bacterial Genomes for the Masses: Relevance to the Clinical Laboratory
Mark J. Pallen

Public Databases: Retrieving and Manipulating Sequences for Beginners
Neil Woodford

Genome Sequencing and Annotation: An Overview
Makoto Kuroda and Keiichi Hiramatsu

Comparative Genomics: Digging for Data
Matthew B. Avison

Genome Plasticity: Insertion Sequence Elements, Transposons and Integrons, and DNA Rearrangement
Peter M. Bennett

Exploring and Exploiting Bacterial Proteomes
Stuart J. Cordwell

Part II. Application of Genomics to Diagnostic Bacteriology

Molecular Diagnostics: Current Opinions
B. Cherie Millar and John E. Moore

Molecular Diagnostics: Future Probe-Based Strategies
Peter Marsh and Donald L. N. Cardy

Real-Time PCR
Nicholas A. Saunders

Microarrays for Bacterial Typing: Realistic Goal or Holy Grail?
Carola Van Ijperen and Nicholas A. Saunders

Part III. Interrogating Bacterial Genomes

Genomic Approaches to Antibacterial Discovery
David J. Payne, Michael N. Gwynn, David J. Holmes, and Marty Rosenberg

Using the Genome to Understand Pathogenicity
Dawn Field, Jennifer Hughes, and E. Richard Moxon

Identification of Novel Pathogenicity Genes by PCR Signature-Tagged Mutagenesis and Related Technologies
Dario E. Lehoux, Francois Sanschagrin, Irena Kukavica-Ibrulj, Eric Potvin, and Roger C. Levesque

Discovering New Pathogens: Culture-Resistant Bacteria
Andrew J. Lawson

Exploring the Concept of Clonality in Bacteria
Brian G. Spratt

Bacterial Taxonomics: Finding the Wood Through the Phylogenetic Trees
Robert J. Owen

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