Genomes, Molecular Biology and Drug Discovery

Genomes, Molecular Biology and Drug Discovery

  • Hardback
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Until recently, the traditional model of pharmaceutical research had been applied to programs of genetic study, resulting in the many therapeutic agents either under developed or in clinical usage. However, a shift in emphasis is currently taking place towards the so-called "Genome Projects" which enable the identification of gene sequences on a much larger scale and have established gene therapy as a more viable route to treatment. They have also forced pharmaceutical research to its "watershed". Genomes, Molecular Biology, and Drug Discovery is based on the 7th SmithKline Beecham International Symposium and attempts to bring the continuing advances in modern genome research and molecular biology together with new pharmacological and chemical strategies sharply into focus. It highlights the need for a multi-disciplinary approach in order to direct the wealth of information accumulated towards better community health care and close the drug discovery loop. Features: * Genome Projects * Interpreting the Code * From Gene to Target * From Target to Therapy * Conclusions and Challenges
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Product details

  • Hardback | 270 pages
  • 154 x 228 x 16mm | 381.02g
  • Academic Press Inc
  • San Diego, United States
  • illustrations, index
  • 0121377903
  • 9780121377908

Table of contents

Genome Projects: The Human Genome Project: What We Want and What We Get. Progress Towards a Complete Set of Human Genes. The Mouse Genome. Interpreting the Code: Exploring the Vast Territory of Uncharted Ests. Prediction of Protein Structures and Their Docking. From Gene to Target: Expressing the Unknown: Considerations in Heterologous Expression of Novel Gene Products to Optimize Determination of Their Functions. The GABA, Receptor Gene Gamily as Targets for Drug Discovery. Drug Discovery in Haemoglobinopathies. From Target to Therapy: Drug Discovery and Optimization Using Binary-Encoded Small Molecule Combinational Libraries. Monoclonal Antibodies: Tools for Exploiting Gene Discovery. Retroviral Vectors: First Generation Systems for Gene Therapy.
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