Genetics and Analysis of Quantitative Traits

Genetics and Analysis of Quantitative Traits

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Description

Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is up-to-date, comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics. Central concepts are developed from first principles and illustrated with wide-ranging examples. The book reflects the recent influx of quantitative-genetic thinking into evolutionary biology and includes the latest techniques for QTL (quantitative-trait loci) analysis. Although written as a general text in quantitative genetics, the book will also serve as a basic reference for the seasoned professional.Website http://nitro.biosci.arizona.edu/zbook/book.htmlshow more

Product details

  • Hardback | 980 pages
  • 188 x 236.2 x 48.3mm | 1,973.15g
  • Sinauer Associates Inc.,U.S.
  • Sunderland, United States
  • English
  • 980 p.
  • 0878934812
  • 9780878934812
  • 316,729

About Michael Lynch

Michael Lynch is Distinguished Professor of Biology at Indiana University. Bruce Walsh is a Professor in the Department of Ecology and Evolutionary Biology at the University of Arizona.show more

Table of contents

I. FOUNDATIONS OF QUANTITATIVE GENETICS.- An Overview of Quantitative Genetics.- Properties of Distributions.- Covariance, Regression, and Correlation.- Properties of Single Loci.- Components of Genetic Variation for Multilocus Traits.- Sources of Environmental Variation.- Resemblance between Relatives.- Introduction of Matrix Algebra and Linear Models.- Analysis of Line Crosses.- Inbreeding Depression.- Matters of Scale.- II. Quantitative Trait Loci.- Polygenes and Polygenic Mutation.- Detecting Major Genes.- Principles of Marker-Based Analysis.- Mapping and Characterizing QTLs: Inbredline Crosses.- Mapping and Characterizing QTLs: Outbred Populations.- III. Estimation Procedures.- Parent-Offspring Regression.- Sib Analysis.- Twins and Clones.- Cross-Classified Designs.- Correlations between Characters.- Genotype x Environment Interaction.- Maternal Effects Sex Linkage and Sexual Dimorphism.- Threshold Characters.- Estimation of Breeding Values.- Variance-Component Estimation with Complex Pedigrees.- Appendices.- Expectations, Variances and Covariances of Compound Variables.- Path Analysis.- Further Topics in Matrix Algebra and Linear Models.- Maximum Likelihood Estimation and Likelihood-Ratio Tests.- Computing the Power of Statistical Tests.- Literature Cited.- Author Index.- Organism and Trait Index.- Subject Index.show more

Review quote

"I have nothing but the highest praise for this book, which will surely stand as the definitive treatment for many years to come. The content is comprehensive, the writing clear and concise, and the overall impression is of a masterly tour de force." --Warren J. Ewens, American Journal of Human Biology"This important and useful book will have a permanent place on my desktop. Not only is this an essential reference book, but it is also an excellent textbook." --Christopher J. Basten, Theoretical Population Biology"Conclusively, this book is to be highly recommended for anyone interested in a closer and clearer look at nature's most valuable beauty--its genetic variability." --Elias Anastassopoulos, Economic Botanyshow more

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