Genetic Diversity Among Jews

Genetic Diversity Among Jews : Diseases and Markers at the DNA Level

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This volume provides an authoritative, up-to-date account of the impact of molecular genetics on our understanding of genetic diseases prevalent among Jews. The extent of genetic variability among different Jewish communities is discussed in detail. After an introductory chapter on major demographic trends of world Jewry, the first part examines ethnohistorical relationships between different Jewish groups in light of nuclear and mictochondrial DNA polymorphisms. The next and largest section of the book reviews the most recent research on some 20 Mendelian disorders (among Ashkenz, Sephardi and Oriental Jews) and the implications of the astonishing molecular heterogeneity revealed in some of them. Advances in genetic aspects of common multifactorial diseases are covered in concluding chapters. This encyclopedic work derives from a conference held in Israel in June 1990. It will be of interest to physicians, genetic counsellors and researchers in medical, molecular, and population more

Product details

  • Hardback | 488 pages
  • 161.8 x 243.6 x 30.2mm | 1,164.49g
  • Oxford University Press Inc
  • New York, United States
  • English
  • frontispiece, halftones, line drawings, tables
  • 0195068173
  • 9780195068177

Table of contents

I. History and Demography: Sergio Dellapergola: Major Demographic Trends of World Jewry: The Last Hundred Years; II. Polymorphisms: Kenneth K. Kidd, Judith R. Kidd, Batsheva Bonne-Tamir, Maria New: Nuclear DNA Polymorphisms and Population Relationships; A.S. Santachiara-Benerecetti, O. Semino, G. Passarino, G.P. Morpurgo, M. Fellous, G. Modiano: Y-Chromosome DNA Polymorphism in Ashkenazi and Sephardi Jews; Uzi Ritte, Esther Neufeld, Batsheva Bonne-Tamir: Types of Mitochondrial DNA Among Jews; Ernest Beutler, W. Kuhl: Variability and Population Genetics of G6PD; Chaim Brautbar, M. Mizrahi, E. Stern, M. Cohen, A. Ziedler, C. Levene, I. Cohen, L. Sherman, R. Sharon, E.D. Albert, T. Cohen: HLA Polymorphism in Ethiopian Jews and Other Jewish and Non-Jewish Groups; Batsheva Bonne-Tamir, Avshalom Zoossmann-Diskin, Aharon Ticher, Ariella Oppenheim, Smadar Avigad, Sandra Kleiman: Genetic Diversity Among Jews Reexamined: Preliminary Analysis at the DNA Level; III: Mendelian Diseases: A. Diseases Present Mainly Among Ashkenazim: Elizabeth F. Neufeld: The Molecular Basis of Tay-Sachs Disease and Related GM2 Gangliosidoses Among Jews and Non-Jews; Edward H. Schuchman, Robert Desnick: Molecular Genetics of Acid Sphingomyelinase and Niemann Pick Disease; Nurit Eyal, Hanna Levy, Orly Reiner, Meir Wigderson, Sylvia Wilder, Mia Horowitz: Gaucher's Disease; James L. German III: Bloom's Syndrome. XVII: The Consequences of Excessive Somatic Mutation; Reuben Matalon, Kimberlee Michals, Rajinder Kaul, Anne B. Johnson: Biochemical and Enzyme Characterization of Canavan Disease; Rei Asakai, Dominic W. Chung, Earl W. Davie, Uri Seligsohn: Heterogenity of Factor XI Deficiency in Ashkenazi Jews; Maria I. New: Nonclassical 21-Hydroxylase Deficiency; Hadas Globerman: Molecular Genetics of 21-Hydroxylase Deficiency; Anat Blumenfeld, Illana Gozes, Felicia B. Axelrod, Hanah Maayan, Ofra Peleg, Simon Godfrey, James A. Trofatter, Laurie Ozelius, Pinchas Shachter, Rina Avidor, Jonathon L. Haines, James F. Gusella, Xandra O. Breakefield: Linkage Analysis in Familial Dysautonomia; Amos D. Korczyn: Genetics of idiopathic Torsion Dystonia in Ashkenazi more