Genetic Control of Malaria and Dengue

Genetic Control of Malaria and Dengue

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Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies.

For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown.

Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmissionProvides a summary of the concepts of both population suppression and population replacementContains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies
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Product details

  • Electronic book text | 488 pages
  • 152 x 229mm
  • Academic Press Inc
  • Oxford, United Kingdom
  • English
  • 0128004053
  • 9780128004050

Table of contents

Section I: Vector-borne disease, global burden and current controls 1. Arboviral/Malaria disease burden (use of vaccines/therapeutics) 2. Critical mosquito vectors and current (non-genetic) methods of control. 3. Vectorial capacity and transmission modeling Section II: Genetic interruption of vectorial capacity 4. Concept and History of genetic control 5. Addition, Subtraction and Multiplication of genes 6. Lifespan/population density 7. Host seeking/host preference 8. Vector competence/Extrinsic incubation period 9. Feeding frequency Section III: Paratransgenesis 10. Wolbachia 11. Manipulation of the mosquito microbiome Section IV: Social, Political and Ethical aspects of genetics-based control 12. Regulation of genetically modified mosquitoes 13. Ethical and ecological ramifications of genetics-based control strategies 14. Stories from the field: lessons from community outreach
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