Generation and expansion of mitochondrial DNA deletions in dopaminergic neurons: new evidences for a direct role of dopamine metabolism
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Generation and expansion of mitochondrial DNA deletions in dopaminergic neurons: new evidences for a direct role of dopamine metabolism

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High levels of mitochondrial DNA deletions have been found in dopaminergic neurons of§Parkinson Disease patients, suggesting a role in the pathology. However, the reason for thisaccumulation of mtDNA deletions is unclear. In this work, dopamine was found to drive this§phenomenon, probably through forcing continuous DNA strand-break repair events. The§results also suggest that mtDNA deletions are acting in combination with other cell-specific§factors, to promote neurodegeneration.show more

Product details

  • Paperback | 126 pages
  • 146 x 208 x 12mm | 264g
  • Apprimus Wissenschaftsver
  • English
  • 3863591348
  • 9783863591342