General Index to Volumes One to Fifty of the Proceedings of the American Pharmaceutical Association from 1852 to 1902, Inclusive
This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1884 edition. Excerpt: ...1883, 91. Piperine--Attificial Production.--Riigheimer describes the successful attempt to build up the alkaloid piperine by the same methods as those adopted by Ladenburg in the preparation of artificial atropine. The action of phosphorus pentachloride upon piperic acid yielded the acid chloride, which was then made to act upon piperidine. The result of the reaction, freed from side products, was piperine, which, after purification by recrystallization from benzol and ligroin, fused at 127 to 128 C., and gave figures on analysis closely according with those demanded by the formula. Natural piperine, according to Riigheimer's observation, fuses at 128 to 129.5 C. In some text books the fusing point of piperine is erroneously given on Pelletier's authority at 100 to 11o0 C.--Am. Jour. Phar., Aug. 1882, 397, from Ber. d. d. Chem. Ges., xv., 1390. Lascrpitin--Isolation and Character.--According to Dr. Richard Kiilz, laserpitin, the bitter principle of the white gentian root (Laserpitium latifolium), is obtained by repeatedly extracting the finely divided root with petroleum ether, the filtered liquids concentrated by distillation, and the residual red-brown liquid allowed to evaporate and crystallize. The crystals are purified by recrystallization from boiling petroleum ether, and then form large colorless crystals of the monoclinic system, having the composition C, H, O, and melting at 118 C. Upon heating laserpitin with sodium acetate and an excess of acetic anhydride, the acetyl derivative, C,6H, (C, H, O)O4, is obtained, which crystallizes in short, thick, colorless needles, melting at 113 C. By the action of KOH, laserpitin is split into laserol and angelic acid. The former could be obtained only as a brown resinous mass; the...
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