GERD : Reflux to Esophageal Adenocarcinoma

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Gastroesophageal Reflux Disease (GERD) is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux.

Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.

The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together a vast amount of disparate literature and presents the entire pathogenesis of reflux disease in one place. In addition to providing a new concept of how gastroesophageal reflux causes cellular changes in the esophagus, GERD also offers a complete solution to a problem that has confused physicians for over a century. Both clinical and pathological information about reflux disease and its treatment are presented. GERD is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike.
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Product details

  • Hardback | 464 pages
  • 215.9 x 279.4 x 25.4mm | 1,338.11g
  • Amsterdam, Netherlands, United States
  • English
  • New
  • Approx. 350 illustrations; Illustrations, unspecified
  • 0123694167
  • 9780123694164

Table of contents

Chapter 1: Overview of Gastroesophageal Reflux Disease

Chapter 2: The Past, Present, and Future of Columnar-Lined (Barrett) Esophagus

Chapter 3: Fetal Development of the Esophagus and Stomach

Chapter 4: Normal Anatomy; Present Definition of the Gastroesophageal Junction

Chapter 5: Histologic Definitions and Diagnosis of Epithelial Types

Chapter 6: Cardiac Mucosa

Chapter 7: New Histologic Definitions of Esophagus, Stomach, and Gastroesophageal Junction

Chapter 8: Pathology of Reflux Disease at a Cellular Level: Part 1-Damage to Squamous Epithelium and Transformation into Cardiac Mucosa

Chapter 9: The Pathology of Reflux Disease at a Cellular Level: Part 2-Evolution of Cardiac Mucosa to Oxyntocardiac Mucosa and Intestinal Metaplasia

Chapter 10: Pathology of Reflux Disease at a Cellular Level: Part 3-Intestinal (Barrett) Metaplasia to Carcinoma

Chapter 11: Pathology of Reflux Disease at an Anatomic Level

Chapter 12: Reflux Disease Limited to the Dilated End-Stage Esophagus: The Pathologic Basis of NERD

Chapter 13: Definition of Gastroesophageal Reflux Disease and Barrett Esophagus

Chapter 14: Diagnosis of Gastroesophageal Reflux Disease, Barrett Esophagus, and Dysplasia

Chapter 15: Research Strategies for Preventing Reflux-Induced Adenocarcinoma

Chapter 16: Rationale for Treatment of Reflux Disease and Barrett Esophagus

Chapter 17: Treatment Strategies for Preventing Reflux-Induced Adenocarcinoma

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Review quote

"An essential reading for whoever treats patients with gastroesophageal reflux disease, from gastroenterologists to surgeons."
--Marco G. Patti, MD, Professor of Surgery, University of California, San Francisco

"All of us who are involved in the care of patients with esophageal adenocarcinoma owe a debt of gratitude to Drs. DeMeester and Chandrasoma for producing the exceptional material contained within this text."
--Donald O. Castell, MD, Professor of Medicine, Director, Esophageal Disorders Program, Medical University of South Carolina

"This timely and authoritative book was written by two masters in the field whose experience spans two decades and includes supervision of studies involving more than 10,000 patients. The book is well written and demonstrates the advantages of having a limited number of authors and a narrow focus - namely, consistency of style and a cohesive philosophy...We therefore feel that this book is essential reading for anyone with an interest in esophageal disease, and particularly in GERD and esophageal adenocarcinoma."
-- The New England Journal of Medicine

"This book is extremely well written, carefully and thoughtfully prepared, and offers the open-minded reader a view of GERD that they would not read in any standard textbook or review article on the subject. The rich descriptions of the histopathology, views on carditis, cardiac intestinal metaplasia; and the microscopic definition of the gastroesophageal junction are valuable to all that study this disease." - Philp O. Katz, Thomas Jefferson University and Albert Einstein Medical Center, Philadelphia, PA, Gastroenterology, 2007

"This book describes a novel, fascinating, straight-forward approach towards understanding and management of gastroesophageal reflux disease(GERD), a disease that is `all about us'. The book is highly recommended to those who want to become better in the management of their patients with gastroesophageal reflux disease." - Johannes Lenglinger and Martin Riegler, European Surgery, 2007.

"We therefore feel that this book is essential reading for anyone with an interest in esophageal disease, and particularly in GERD and esophageal adenocarcinoma" - Subhas Banerjee and Jacques Van Dam, Stanford University School of Medicine, 2007
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About Tom R. Demeester

Dr. Parakrama Chandrasoma was born in Sri Lanka and received his medical education and initial pathology training in the Medical School of the University of Sri Lanka. He has postgraduate degrees in internal medicine, including the M.D. (Sri Lanka) and Membership of the Royal College of Physicians (UK). He immigrated to the United States in 1978. Upon completing his pathology residency, he assumed duties as Chief of Surgical Pathology at the Los Angeles County + University of Southern California Medical Center He has held this position since. After an initial interest in neuropathology, Dr. Chandrasoma joined Dr. Tom DeMeester's Foregut Surgery team as pathologist in 1991. This led to a productive study of gastroesophageal reflux disease spanning 16 years and resulting in the development of numerous original concepts relating to the pathogenesis of gastroesophageal reflux disease. Dr. Chandrasoma has written over 140 peer reviewed papers and 6 previous pathology textbooks, including a general text on Gastrointestinal Pathology and a text on Gastroesophageal Reflux Disease, and is a Professor of Pathology at the Keck School of Medicine at the University of Southern California. He is married with three children and lives in Pasadena, California. Professor of Clinical Surgery and Chair of the Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Professor of Clinical Surgery and Chair of the Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
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