GABAb Receptor Pharmacology: A Tribute to Norman Bowery: Volume 58

GABAb Receptor Pharmacology: A Tribute to Norman Bowery: Volume 58

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This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.

The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.
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Product details

  • Hardback | 520 pages
  • 157.48 x 233.68 x 25.4mm | 816.46g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 58th edition
  • 0123786479
  • 9780123786470

Table of contents

Historical Perspective and Emergence of the GABAB Receptor
Norman Bowery

Chemistry of GABAB Receptor Ligands
Wolfgang Froestl

Heterodimerization of the GABAB Receptor - Implications for GPCR Signaling and Drug Discovery
Fiona H. Marshall and Steven M. Foord

Mechanisms of GABAB Receptor Exocytosis, Endocytosis and Degradation
Deitmar Benke

Functional Modulation of GABAB Receptors by Protein Kinases and Receptor Trafficking
Miho Terunuma, Andres Couve, Menelas N. Pangalos, and Stephen J. Moss

GABAB Receptor Coupling to G Proteins and Ion Channels
Claire Padgett and Paul A. Slesinger

GABAB Receptor-mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons
M. Kano and Toshihide Tabata

GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?
Guillermo Gonzalez-Burgos

The Role of GABAB Receptors in Cortical Network Activity
Michael M. Kohl and Ole Paulsen

GABAB Receptors: Physiology Functions and Mechanisms of Diversity
Andree Pinard, Riad Seddik, and Bernhard Bettler

Role of GABAB Receptors in Autonomic Control of Systemic Blood Pressure
De-Pei Li and Hui-Lin Pan

GABAB Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease
Anders Lehmann, Jorgen Jensen, and Guy E. Boeckxstaens

GABAB Receptors in Reward Processes
Styliani Vlachou and Athina Markou

GABAB Receptors in Addiction and Its Treatment
David J. Nutt, Anne Lingford-Hughes, Laurence John Reed, and Robin J. Tyacke

GABAB - GIRK2 Mediated Signaling in Down Syndrome
Nathan Cramer, Tyler Best, and Zygmunt Galdzicki

GABAB Receptors and Depression: Current Status
John F. Cryan and David A. Slattery

GABAB Receptors in Drosophila

Hari Manev and Svetlana Dzitoyeva
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