G. Proteins : Signal Transduction and Disease
G-Proteins play a vital part in the regulation of transmembrane signalling cascades in a wide variety of cell types. As one might expect, alterations in their expression and function are apparent in many diseases. This book aims to address all the available information on modulations of the effectiveness of G-Protein mediated signal transduction in clinical disorders, ranging from alcoholism to cancers of the haemopoetic and pituitary systems. Against the context of normal signal transduction, the authors discuss whether alterations in G-Protein expression and function are the consequence or a symptom of various diseases states and examine the potential of pharmacological intervention in these processes.
- Hardback | 260 pages
- 152 x 229 x 17mm | 513g
- 01 May 1992
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
Table of contents
Guanine nucleotide binding proteins in health and disease, G. Milligan; mutations within the gene encoding the simulatory G-Protein of adenyl cycalse as the basis for Albright hereditary osteodystrophy, A. Miric and M.A. Levine; GTP- binding proteins and cardiovascular disease, K. Urasawa and A. Insel; alterations in G-Protein mediated cells signalling in diabetes mellitus, C.J. Lynch and J.H. Exton; adrenal dysfunction and G-Protein mediated pathways, J.R. Hadcock and C. Malbon; G-Proteins in obesity, N. Begin-Heich and N. McFarlane-Anderson; thyroid disorders, D. Saggerson; alcoholism - a possible G-Protein; disorder, A.S. Gordon, et al; the role of G-Proteins in the regulation of myeloid haemopoietic cell proliferation and transformation, P. Musk, et al.