G Protein-Coupled Receptors: Volume 132

G Protein-Coupled Receptors: Volume 132 : Signaling, Trafficking and Regulation

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G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation.
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Product details

  • Hardback | 502 pages
  • 191 x 235 x 30.48mm | 1,250g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128035951
  • 9780128035955

Table of contents

Section 1 Trafficking, Localization and Imaging of GPCRs
1. Localization and Signaling of GPCRs in Lipid Rafts
Van Anthony M. Villar, Santiago G. Cuevas, Xiaoxu Zheng, Pedro A. Jose
2. Imaging GPCRs Trafficking and Signaling with Total Internal Reflection Fluorescence Microscopy in Cultured Neurons
Francheska Delgado-Peraza, Carlos Nogueras-Ortiz, Agnes M. Acevedo Canabal, Cristina Roman-Vendrell, Guillermo A. Yudowski
3. Trafficking of Ciliary G-Protein Coupled Receptors
Jeremy McIntyre, Mellisa M. Hege, Nicolas F. Berbari
4. Single Molecule Resolution of G Protein-Coupled Receptor (GPCR) Complexes
Kim C Jonas, Ilpo Huhtaniemi, Aylin C Hanyaloglu
5. Quantification of the mRNA Expression of G-protein Coupled Receptors in Human Adipose Tissue
Stefan Amisten
Section 2 Signaling and Regulation of GPCRs
6. Studying the Regulation of Endosomal cAMP Production in GPCR Signaling
Alexandre Gidon, Timothy N. Feinstein, Kunhong Xiao, Jean-Pierre Vilardaga
7. GPCR-Radioligand Binding Assays
Colleen A. Flanagan
8. Assessing Smoothened-Mediated Hedgehog Signaling in Zebrafish
Teresa Casar Tena, Melanie Philipp
9. GPCRs and Actin-Cytoskeleton Dynamics
Genaro Vazquez-Victorio, Claudia Gonzalez-Espinosa, Zyanya P. Espinosa-Riquer, Marina Macias-Silva
Section 3 Cellular Assays for GPCRs
10. Olfactory Receptor Signaling
Gabriela Antunes, Fabio Marques Simoes de Souza
11. Tracking GPCR Biosynthesis and Degradation Using a Non-Radioactive Pulse Chase Methodology
Richard B. Vallee Richard Wargachuk, Dominic Devost, Cynthia Zhou, Terence E. Hebert
12. Tango Assay for Ligand Induced GPCR - ss-arrestin2 Interaction: Application in Drug Discovery
Shalini Dogra, Chandan Sona, Ajeet Kumar, Prem N Yadav
13. Resonance Energy Transfer-Based Approaches to Study GPCRs
Mohammed Akli Ayoub
14. Quantitative Analysis of G Protein-Coupled Receptor Internalization Using DnaE Intein-Based Assay
Bin Lu, Linjie Chen, Yaping Zhang, Ying Shi, Naiming Zhou
15. Cellular and Subcellular Context Determine Outputs from Signalling Biosensors
Dominic Devost, Nicolas Audet, Cynthia Zhou, Hiroyuki Kobayashi, Helene Bonin, Viktorya Lukashova, Christian Le Gouill, Michel Bouvier, Terence E. Hebert
Section 4 Structural and Computational Investigation of GPCRs
16. Protease-Activated Receptors PARs in Cancer: Novel Biased Signaling and Targets for Therapy
Bar-Shavit R, Maoz M, Kancharla A, Jaber M, Agranovich D, Grisaru-Granovsky S, Uziely B
17. Computational Methods for Studying G Protein-Coupled Receptors (GPCRs)
Agnieszka A. Kaczor, Ewelina Rutkowska, Damian Bartuzi, Katarzyna M. Targowska-Duda, Dariusz Matosiuk, Jana Selent
18. Comparing Class A GPCRs to Bitter Taste Receptors: Structural Motifs, Ligand Interactions and Agonist-to-Antagonist Ratios
Antonella Di Pizio, Anat Levit, Michal Slutzki, Maik Behrens, Rafik Karaman, Masha Y Niv
19. What Can Simulations Tell Us About GPCRs: Integrating the Scales
Durba Sengupta, Manali Joshi, Chaitanya A. Athale, Amitabha Chattopadhyay
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About Arun K. Shukla

Dr. Arun K. Shukla obtained his M.Sc. (Master in Science) from the Center for Biotechnology at the Jawaharlal Nehru University in New Delhi, India. Dr. Shukla did his Ph.D. from the Department of Molecular Membrane Biology at the Max Planck Institute of Biophysics in Frankfurt, Germany. His Ph.D. research work was focused on structural studies of G Protein-Coupled Receptors (GPCRs). Dr. Shukla subsequently carried out his post-doctoral work in the Department of Medicine at the Duke University in North Carolina, USA. During his post-doctoral research work, Dr. Shukla focused on understanding the biophysical and structural basis of ss-arrestin mediated regulation of GPCRs and non-canonical GPCR signaling. Dr. Shukla has served as an Assistant Professor in the Department of Medicine at the Duke University in Durham, North Carolina, USA.Dr. Shukla is currently an Assistant Professor in Department of Biological Sciences and Bioengineering at the Indian Institute of Technology, Kanpur, India. Dr. Shukla is also an Intermediate Fellow of the Wellcome Trust-DBT India Alliance. The research program in Dr. Shukla's laboratory is focused on understanding the molecular mechanism of activation, signaling and regulation of G Protein-Coupled Receptors.
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