G Protein-Coupled Receptors in Health and Disease, Part A: Volume 88

G Protein-Coupled Receptors in Health and Disease, Part A: Volume 88

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Description

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.
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Product details

  • Hardback | 224 pages
  • 152.4 x 228.6 x 20.32mm | 294.83g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 88th edition
  • Illustrations (some col.)
  • 0123747570
  • 9780123747570

Review quote

PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."-British Medical Journal
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Table of contents

1. Rhodopsin-Mediated Retinitis Pigmentosa

Katherine M. Malanson and Janis Lem

2. Human Diseases Associated with GPR54 Mutations

Milena Gurgel Teles, Leticia Ferreira Gontijo Silveira, Suzy Bianco and Ana Claudia Latronico

3. Diseases Associated with Growth Hormone-releasing hormone Receptor (GHRHR) Mutations

Marco Martari and Roberto Salvatori

4. The Melanocortin-1 Receptor Gene Polymorphism and Association with Human Skin Cancer

Kimberley A. Beaumont, Yan Yan Liu and Richard A. Sturm

5. The Molecular Basis of Adrenocorticotrophin Resistance Syndrome

Lucila L K Elias and Adrian J L Clark

6. Mutations in melanocortin-4 receptor and human obesity

Ya-Xiong Tao
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About Ya-Xiong Tao

Dr. Ya-Xiong Tao is currently Associate Professor of Physiology at Auburn University College of Veterinary Medicine in Auburn, Alabama, USA. He has been working on several G protein-coupled receptors, including gonadotropin receptors regulating reproduction, and melanocortin receptors regulating energy and glucose homeostasis. He has published extensively in peer-reviewed biomedical journals and obtained funding for his research from National Institutes of Health, American Diabetes Association and American Heart Association, among others. He has delivered numerous lectures at universities and research institutes in USA. Canada, and China. He is visiting or guest professors at four universities and research institute in China. He has edited four volumes in Progress in Molecular Biology and Translational Science and is editing a volume of Advances in Pharmacology. He teaches several courses, including Physiology, Receptorology, and Molecular Endocrinology, for veterinarian and graduate students.
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