Frontotemporal Dementia

Frontotemporal Dementia

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Description

Frontotemporal Dementia provides an in-depth look at the history, various types, genetics, neuropathology and psychosocial aspects of one of the most common but least understood causes of dementia, frontotemporal lobar degeneration, from one of the world's leading centers for the study of dementia. Aided by the latest research in diagnosis, mechanism and treatment, this book captures the rich and quickly changing landscape of a devastating neurodegenerative disease, and offers up-to-date clinical advice for patient care. Frontotemporal dementia, in particular, raises psychological and philosophical questions about the nature of self, free will, emotion, art and behavior - important topics for practitioners and families to appreciate as they care for the sufferer. This book includes case studies, photographs and figures from the leaders in the field and personal communication from the researchers driving these developments.show more

Product details

  • Hardback | 200 pages
  • 172.72 x 256.54 x 15.24mm | 680.39g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 0195380495
  • 9780195380491
  • 1,084,051

About Bruce L. Miller

Bruce L. Miller, MD is Professor of Neurology at the University of California, San Francisco (UCSF) where he holds the A.W. & Mary Margaret Clausen Distinguished Chair, teaches extensively and directs the busy UCSF dementia center. He is a behavioral neurologist focused in dementia with special interests in brain and behavior relationships as well as the genetic and molecular underpinnings of disease.show more

Review quote

Frontotemporal Dementia by Bruce Miller is a remarkable book. Presenting the exciting science of this rapidly progressive field, the book is comprehensive, up-to-date, and clinically relevant. While introducing the latest advances in genetics, imaging, and neuropathology, Frontotemporal Dementia captures the author's important perspective on the philosophical issues raised by these unique disorders regarding how they impact our understanding of our sense of self and our role in the human community. This milestone volume is the definitive reference on frontotemporal dementias. -- Jeffrey Cummings, MD, Director, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV "This is an exciting and authoritative book on frontotemporal dementia (FTD) that spans the biological and clinical features of a fascinating disease that sits directly in the intersection between neurology, psychiatry and neuroscience. It elucidates key principles around the biological basis for abnormal behavior. The superbly written book is a comprehensive guide for the physicians, psychologists, neuroscientists, and others who work with FTD and is very highly recommended." -- Dilip V. Jeste, M.D., President, American Psychiatric Association Frontotemporal lobar degenerations are being recognized with increasing frequency by the practicing neurologist. They are also offering unique research opportunities for exploring the molecular foundations of selective vulnerability and the neurobiology of cognitive networks. In this lavishly illustrated monograph, Bruce Miller integrates the history, clinical manifestations, cognitive patterns, neuropathology, genetics and even philosophical implications of FTD into a comprehensive account that is as readable as it is authoritative. This volume offers the single most coherent account of the topic that I have yet encountered. -- M-Marsel Mesulam, MD, Ruth and Evelyn Dunbar Professor of Neurology, Psychiatry and Psychology, Director, The Cognitive Neurology and Alzheimer's Disease Center (CNADC), Feinberg School of Medicine, Northwestern University, Chicago, IL "This book will be helpful to neurologists, neuropsychologists, neuropsychiatrists, those who specialize in geriatrics, and specially those who have patients with frontotemporal dementia. ... This book authored by Dr. Bruce Miller is a very important source of information on FTD, and includes case studies and Reference lists at the end of chapters on other books and sources of information and research on similar subjects. Its value is enhanced with black-and-white and multicolor brain scans, boxes, charts, tables, and other features." --Biz Indiashow more

Table of contents

Table of Contents ; 1. History and Nomenclature ; Pick's Disease: The Contributions of Arnold Pick ; Maintaining Early Traditions and Refining Diagnosis: Delay, Brion, Escourolle, Malamud and Constantinidis ; Splintering of Pick's Disease into Multiple Subtypes ; The Biological Revolution ; FTD Now: Where Are We? ; The Future ; References ; 2. The Clinical Syndrome of bvFTD ; Overview ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; BVFTD: Current State And Research Advances ; References ; 3.The Clinical Syndrome of NFVPPA ; Overview ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; NFVPPA: Current State And Research Advances ; References ; Related Disorders: FTD-ALS ; Overview ; Amyotrophic Lateral Sclerosis ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; FTD-ALS: Current State and Research Advances ; References ; 6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy ; Overview ; Creativity ; Treatment ; svPPA: Current State and Research Advances ; Semantic Knowledge and the Anterior Temporal Lobes ; Autoimmunity, Left-Handedness, Head Trauma and svPPA ; Summary ; References ; 4. Progressive Nonfluent/Agrammatic Aphasia ; Overview ; Case History ; Comment ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; nfvPPA: Current State and Research Advances ; Diagnosis from Clinical Syndrome to Molecular Diagnosis ; Neurolinguistic and Neuroplasticity Discoveries ; References ; 5. Related Disorders: FTD-ALS ; Overview ; Amyotrophic Lateral Sclerosis ; Case History ; Comment ; Clinical Features and Anatomy ; El Escorial Criteria ; Genetic and Pathological Correlates ; Neuropathology ; Differential Diagnosis ; Treatment ; FTD-ALS: Current State and Research Advances ; Clinical-Pathological Considerations ; Molecular Considerations ; References ; 6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy ; Overview ; Corticobasal Degeneration (CBD) ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; Progressive Supranuclear Palsy (PSP) ; Clinical Features and Anatomy ; Genetic and Pathological Correlates ; Differential Diagnosis ; Treatment ; CBD and PSP: Current State and Research Advances ; References ; 7. A Primer of FTLD Neuropathology ; General Features ; Overview of Tau-Related Neuropathology in FTLD ; Overview of TDP-43 and FUS Related Neuropathology in FTLD ; Gross Anatomical and Microscopic Changes in FTLD ; Special Features of FTLD Pathology ; FTLD Neuropatholoy: Current State and Research Advances ; 8. FTD Genes ; Overview ; Genes Implicated in FTD ; Genes That Modify FTD Expression ; Management and Genetic Counseling ; References ; 9. FTD Reflections Upon Psychology and Philosophy ; Emotions ; The Self ; Free Will ; Religious Beliefs ; Psychology ; von Economo Neurons ; References ; 10. Treatments ; Diagnosis ; bvFTD: Targeting Symptoms, Educating the Family ; svPPA: Targeting Symptoms, Educating the Family ; nfvPPA: Targeting Symptoms and Educating the Family ; Late Stages of FTD ; Early Interventions ; Pharmacological Review ; Non-Pharmacological Therapies ; Complementary and Alternative Medicine ; Language Impairment ; Future Treatments ; Conclusions ; Referencesshow more

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