From Melanocytes to Melanoma

From Melanocytes to Melanoma : The Progression to Malignancy

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Description

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.show more

Product details

  • Hardback | 678 pages
  • 186 x 258 x 40mm | 1,841.61g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 124 black & white illustrations, 6 colour illustrations
  • 1588294595
  • 9781588294593

Review quote

From the reviews: "...this compendium of current thinking is recommended reading for anyone with an interest in pigmentation and cancer and a valuable resource for any library." -Melanoma Research "This book, the first of its kind on melanoma, details the current state of our knowledge ... . should be viewed as an important resource for understanding the broad field of melanocyte and melanoma biology. Newcomers to the field ... will find this book extremely useful. ... This book captures the tremendous progress made in the field ... . It is a valuable resource for biologists and basic scientists ... as well as for pathologists; dermatologists, surgeons, and medical oncologists ... ." (Lynn M. Schuchter, The New England Journal of Medicine, March, 2007) "...captures the tremendous progress made in the field...will help to propel the field to new successes...a valuable resource for biologists and basic scientists interested in the biology of pigment cells as well as for pathologists, dermatologists, surgeons, and medical oncologists interested in the diagnosis and treatment of melanoma." -New England Journal of Medicine "The editors have compiled a highly prestigious group of authors, who are leaders in the field of melanocyte and melanoma research, to present a very comprehensive exposition of the current knowledge of melanocyte biology and melanoma. ... As a clinical researcher, I found ... it fascinating, yielding a tremendous appreciation for the meticulous and extensive work that has been done to date, some of which has and more of which will very likely provide leads to clinical interventions." (Janice P. Dutcher, Medical Oncology, Vol. 23 (3), 2006) "An extremely detailed book on each of the various pathways, growth factors, and oncogenes affecting the melanocyte. This is a comprehensive review and ... physicians such as dermatologists, pathologists, and oncologists will find it helpful. It is very thorough in its presentation of cellular events ... . This book will serve primarily as a reference for basic scientists and biologists. Physician scientists will also use the book. Clinicians may find the book highly detailed, with more information then they require." (Mary C. Martini, Doody's Review Service, July, 2006)show more

Back cover copy

Melanoma offers an excellent model for cancer biology and an opportunity to understand the progression of a normal skin cell-the melanocyte-to malignancy. In From Melanocytes to Melanoma: The Progression to Malignancy, leading researchers and clinicians join forces to explain how skin cancer develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, the malignant transformation of melanocytes, and the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The text is augmented by four color plates. Comprehensive and illuminating, From Melanocytes to Melanoma: The Progression to Malignancy, provides pathologists, dermatologists, surgeons, and medical oncologists with an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.show more

Table of contents

Part I. Melanocyte Development and Function The Origin and Development of Neural Crest-Derived Melanocytes Debra L. Silver and William J. Pavan MITF: A Matter of Life and Death for Developing Melanocytes Heinz Arnheiter, Ling Hou, Minh-Thanh T. Nguyen, Keren Bismuth, Tamas Csermely, Hideki Murakami, Susan Skuntz, WenFang Liu, and Kapil Bharti MITF: Critical Regulator of the Melanocyte Lineage Erez Feige, Laura L. Poling, and David E. Fisher Melanocytes and the Transcription Factor Sox10 Michael Wegner Human Cutaneous Pigmentation: A Collaborative Act in the Skin, Directed by Paracrine, Autocrine, and Endocrine Factors and the Environment Zalfa A. Abdel-Malek and Ana Luisa Kadekaro Melanocyte Distribution and Function in Human Skin: Effects of Ultraviolet Radiation Yuji Yamaguchi and Vincent J. Hearing Part II. Melanocyte Transformation and Progression to Melanoma Altered Signal Transduction in Melanoma Pablo Lopez Bergami, Anindita Bhoumik, and Ze'ev Ronai BRN2 in Melanocytic Cell Development, Differentiation, and Transformation Anthony L. Cook, Glen M. Boyle, J. Helen Leonard, Peter G. Parsons, and Richard A. Sturm The Dynamic Roles of Cell-Surface Receptors in Melanoma Development Dong Fang and Meenhard Herlyn Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation Dorothy C. Bennett Genetic Progression From Melanocyte to Malignant Melanoma Boris C. Bastian The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma Dahu Chen, Qiushi Lin, I. Saira Mian, Jon Reed, and Estela E. Medrano RB/E2F Regulation and Dual Activity in the Melanocytic System Ruth Halaban Melanoma Development and Pigment Cell Transformation Claudia Wellbrock The Biology and Genetics of Melanoma Norman E.Sharpless and Lynda Chin The Biology of Xeroderma Pigmentosum: Insights Into the Role of Ultraviolet Light in the Development of Melanoma James E. Cleaver Divergent Pathways to Cutaneous Melanoma David C. Whiteman and Adele C. Green Pigmentation, DNA Repair, and Candidate Genes: The Risk of Cutaneous Malignant Melanoma in a Mediterranean Population Maria Teresa Landi Low-Penetrance Genotypes, Pigmentation Phenotypes, and Melanoma Etiology Peter A. Kanetsky and Timothy R. Rebbeck The Biology of Melanoma Progression: From Melanocyte to Metastatic Seed A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr. Optical Imaging Analysis of Atypical Nevi and Melanoma Amanda Pfaff Smith and Dorothea Becker Proteomics Analysis of Melanoma Cell Lines and Cultured Melanocytes Katheryn A. Resing and Natalie G. Ahn Part III. Primary Invasive Melanoma to Metastatic Melanoma Paradigm of Metastasis for Malignant Melanoma Stanley P. L. Leong Repair of UV-Induced DNA Damage and Melanoma Risk Qingyi Wei High-Risk Factors for Melanoma Metastasis Neil A. Accortt and Seng-jaw Soong Role of Melanoma Inhibitory Activity in Early Development of Malignant Melanoma Anja-Katrin Bosserhoff Role and Regulation of PAR-1 in Melanoma Progression Carmen Tellez and Menashe Bar-Eli Molecular Mechanisms of Melanoma Metastasis Mohammed Kashani-Sabet Overview of Tumor Progression in Melanoma David E. Elder The Plasticity of Melanoma Cells and Associated Clinical Implications Mary J. C. Hendrix, Elisabeth A. Seftor, Angela R. Hess, and Richard E. B. Seftor The Clinical Use of Molecular Markers as Predictors of Disease Outcome and Response to Therapy in Malignant Melanoma Steve R. Martinez, Hiroya Takeuchi, Dave S. B. Hoon The Roleshow more