This publication is focused on coenzyme Q. The topics span from biochemical aspects to biomedical implications and clinical use of CoQ10. Several papers are focused on bioenergetics and on biosynthesis; new work is presented on the existence of supercomplexes of the mitochondrial respiratory chain and the role of coenzyme Q diffusion in membranes. The antioxidant aspects as well as the non-mitochondrial electron transport systems are addressed. Coenzyme Q biosynthesis is more deeply investigated in yeast and in Caenorhabditis elegans. Some articles refer to plasma and tissue concentrations of CoQ10, including values in childhood. Physiological and clinical issues are also deeply investigated: they confirm the use of coenzyme Q10 as a coadjuvant in the treatment of different pathologies involving energy deficiency or oxidative stress. Studies on cardiovascular disease and on neurological syndromes are reported. The effect of CoQ10 administration on ageing is addressed in some animal models. Moreover, clinical trials are presented on new fields, for CoQ research, such as age-related macular degeneration and idiopathic asthenozoospermia.
This book provides a deeper insight into the multifaceted use of Coenzyme Q, and it is of interest to a large number of readers working in different biochemical and medical fields.show more