Foundations of Structural Biology

Foundations of Structural Biology

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Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules.
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Product details

  • Paperback | 168 pages
  • 222.3 x 279.9 x 15.7mm | 582.25g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0120777002
  • 9780120777006

Table of contents

Introduction to Protein Structure.
Solid State and Solution Methods for Determining Biological Macromolecular Structure.
Crystallographic Coordinates and Stereodrawings.
Properties of Biomacromolecules in the Crystalline State.
Quaternary Structure of Proteins.
Secondary Structure of Proteins.
Domains and Super-secondary Structure.
Conformational States in Crystal and NMR Structures.
Hydrogen Bonds and Water Molecules in Crystalline Proteins.
Protein and Nucleic Acid Complexes.
Metal Ions Bound to Proteins.
Lipid Protein Interactions.
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Review quote

"This well-written book describes the principles of modern structural biology as derived from the analysis of the hardcore data from X-ray diffraction and NMR studies of protein structure.
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