Forensic DNA Typing

Forensic DNA Typing : Biology and Technology Behind STR Markers

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Forensic DNA Typing focuses on the biology and technology behind short tandem repeat (STR) markers and the most common forensic DNA analysis method used today. This comprehensive handbook will help forensic scientists gain a better understanding of STRs and the procedures needed to properly analyze them, while helping professionals in the law enforcement and legal communities comprehend the complexities of DNA profiling. It will also help laboratories meet the training requirements in the new DNA Advisory Board Quality Assurance Standards. The first few chapters of Forensic DNA Typing provide a thorough introduction to the topic for readers who might be less familiar with DNA, while providing a useful review for more advanced readers. It goes on to cover new genetic markers and information on rapidly changing technologies to help professionals make accurate identifications through DNA typing. Detailed illustrations and examples are used throughout. The book concludes with reviews of the DNA testing performed in high-profile cases such as the O.J.
Simpson trial, the President Clinton-Monica Lewinsky affair, the Tomb of the Unknown Soldier, the Thomas Jefferson-Sally Hemings family controversy, and others. John Butler has been involved in the validation of the short tandem repeat markers that form the basis of the FBI's nationwide DNA database, CODIS, and in the development of new and innovative technologies. His talent for explaining complex information is apparent in the clear organization, illustrations, and straightforward language of this text. Forensic DNA Typing has already established itself as the standard reference in the field. Key Benefits: * Chapters cover the topic from introductory level right up to cutting edge research * Forensic scientists learn about the new methods and technologies required by STR typing * DNA laboratories find out how to meet the training requirements of the DNA Advisory Board Quality Assurance Standards (listed in Appendix III) * Lawyers and law enforcement professionals understand the science behind the techniques * All readers can use the information listed on suppliers of DNA analysis equipment, products and services
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Product details

  • Hardback | 333 pages
  • 195.3 x 253.5 x 22.6mm | 1,045.05g
  • Academic Press Inc
  • San Diego, United States
  • English
  • colour and b&w illustrations
  • 012147951X
  • 9780121479510

About John M. Butler

John Butler earned his Ph.D. from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He designed and built STRBase--an Internet-accessible database on short tandem repeat DNA markers that is widely used by forensic scientists today. He is a frequent author and presenter on the topic of DNA typing.
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Table of contents

Foreword; Introduction; Acknowledgements; Overview and History of DNA Typing; Biology; DNA Biology Review; Sample Collection and Preparation (DNA Extraction and Quantification); The Polymerase Chain Reaction (DNA Amplification); Commonly Used Short Tandem Repeat Markers; Biology of STRs: Stutter Products, Non-Template Addition, Microvariants, Null Alleles, and Mutation Rates; Forensic Issues: Degraded DNA, PCR Inhibition, Contamination, and Mixed Samples; Additional DNA Markers: Amelogenin, Y-Chromosome STRs, mtDNA, SNPs, Alu Repeats; Technology; DNA Separation Methods: Slab-Gel and Capillary Electrophoresis; DNA Detection Methods: Fluorescent Dyes and Silver Staining; The ABI Prism 310 Genetic Analyzer; The Hitachi FMBIO II Fluorescence Imaging System; STR Genotyping Issues; Laboratory Validation; New Technologies and Automation; Combined DNA Index System (CODIS) and the Use of DNA Database; Biology, Technology and Genetics; DNA Testing in High-Profile Cases; Appendix I: Reported STR Alleles: Sizes and Sequences; Appendix II: CEPH Family Study; Appendix III: DNA Advisory Board Quality Assurance Standards; Appendix IV: Suppliers of DNA Analysis Equipment, Products, or Services; Index;
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Review quote

"...a well written and informative book...The author has succeeded in presenting complex biological and technical information on STR markers in a way that allows the reader to clearly visualize and understand the principles involved...this book would serve as an excellent introductory textbook for students in forensic science or as a reference text for scientists employed in forensic biology or related fields. - Peter Bilous, RCMP Forensic Laboratory Services, Edmonton, Alberta, Canada, for the CANADIAN SOCIETY OF FORENSIC SCIENCES JOURNAL, December 2001 Forensic DNA Typing provides a wealth of general and background information on STRs and details on current and future technologies employed in forensic DNA typing...I would strongly recommend this book as a training aid for new analysts or a DNA typing reference for forensic scientists. - Brendan F. Shea, DNA Analysis Unit, Federal Bureau of Investigation, for FORENSIC SCIENCE COMMUNICATIONS As a guide and reference for the non-specialist this book is extremely useful. The practical details and methods make it a valuable purchase for scientists, doctors, lawyers and police officers. It is clear and practical. The chapter of case studies at the end puts informative flesh on the subject which is still mysterious to many in the forensic field. The book goes a long way to demystifying DNA and I would recommend it highly. Winner of the Highly Commended Award for 2001 - British Medical Association ...While there are many books that discuss the principles of molecular biology and forensic testing, none have dealt solely with the biology, technology, and applications of DNA typing in such a comprehensive fashion as this one. Dr. Butler has a unique perspective on DNA typing. His background...uniquely [qualifies] him as an expert in the forensic field...a very readable text... --Dennis J. Reeder, Ph.D., FBI DNA Advisory Board, from the Foreword ...the book has so many qualities that it is worth considering for everybody who is involved in modern forensic genetic DNA typing or is dependent on the results and the interpretation of the results. - Internet Journal of Forensic Medicine
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Rating details

40 ratings
4.37 out of 5 stars
5 57% (23)
4 32% (13)
3 5% (2)
2 0% (0)
1 5% (2)
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