Excerpt from Fifth Scientific Report on the Investigations of the Imperial Cancer Research Fund: Under the Direction of the Royal College of Physicians of London and the Royal College of Surgeons of England
Reports, and on this occasion reference need be made only to two figures published in the Fourth Scientific Report On page 208, fig. 69, a chart of tumour-strain 63 is given, where in everv animal inoculated a progressively growing tumour has developed. On page 195, fig. 61 a, a chart of tumour 206 appears, but in this case all the growths which developed finally disappeared spontaneously. Both of these figures are reproduced here (figs.1 and 2) for the convenience of the reader. These two carcinomatous strains exemplify the possible extremes of type of growth, and the intermediate gradations between them have been actually filled up in practice in this laboratory by the cultivation of a large number of different tumour-strains. There must be one or more factors in constant operation to give the two extreme results cited above, and the understanding of these phenomena has to a considerable extent been advanced by Bashford, Murray, and Haaland (10, since they have shown that the resistance to re-inoculation which a tumour - bearing animal frequently exhibits, is of the nature of an active immunity. This development of an active immunity or rather resistance during the growth of a transplanted tumour (concomitant immunity) is a most important factor in determining the character of growth which a tumour will show, and the following experiments demonstrate this in as clear a manner as can be expected from a biological experiment.
The procedure adopted in the experiments now to be described has been to inoculate in one ﬂank a series of animals with a given tumour strain, and then to extirpate surgically all the growths after 10-30 days, i. E. After intervals long enough to allow the tumours to attain a considerable sipe, 1 - 4 grammes. It may here be mentioned that young animals Of the same breed, about 6 - 8 weeks old and weighing 14 - 18 grammes, have been used throughout. One, two, or three days after extirpation, the animals have been re-inoculated on the other ﬂank with a tumour of the same or of another strain. In this way two readings are obtained the result of inoculating a given series of normal animals, and the result of inoculating the same animals after a tumour had been growing in them over a known period. The precise way in which the experiments have been carried out will be rendered clearer by the accompanying charts which portray the tumours first inoculated as black silhouettes, whilst the tumours inoculated after operation, as also the controls to the second inoculation, are given in red. In addition, such data as the date of inoculation, of re inoculation, of recording the result, the amount of tumour-tissue injected, etc., have also been printed on the charts.
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