Females are Mosaics

Females are Mosaics : X Inactivation and Sex Differences in Disease

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Description

Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The father's copy works in some cells, while the mother's copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women.show more

Product details

  • Hardback | 284 pages
  • 160 x 233.7 x 22.9mm | 567g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 8 pp colour plates, 24 halftones, 35 line illustrations, tables
  • 0195188128
  • 9780195188127

Review quote

"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature"I thoroughly enjoyed reading this book...This important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature"I thoroughly enjoyed reading this book...This important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine"Migeons eyewitness account of the discovery of X inactivation and the investigations of its mechanism is engaging...Biologists will appreciate the breadth of the book and the thorough referencing."--Science"This is a magnificent discussion of the X chromosome function, mechanisms of expression, and the role of the X chromosome in embryogenesis and human pathology.Congratulations are due to Dr. Migeon for a job well done. This is a unique book with very few omissions. Reading it is a pleasure and the author adheres to her goals and provides unique information in a manner I have not seen before. This book has no comparison and I look forward to updated editions." --Doody'sshow more

Table of contents

Introduction; PART I. BACKGROUND; 1. Sex Differences in Disease; 2. Evolution of the Human Sex Chromosomes and a Portrait of the Human X; 3. X Chromosome Dosage Compensation: An Overview; 4. The Discovery of X Chromosome Inactivation; 5. Experimental Models for X Inactivation Studies; PART II. THEMES AND VARIATIONS OF X INACTIVATION; 6. Theme 1: The Initial Steps - Creating the Active and Inactive X; 7. Theme 2: The Subsequent Steps - Spreading and Maintaining Inactivation; 8. Variations 1: Stability of the Inactive X; 9. Variations 2: Choice of Active X; PART III. MEDICAL CONSEQUENCES OF X INACTIVATION; 10. The Single Active X; 11. Mosaicism; 12. Determinants of Female Phenotypesshow more

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