Extracellular Matrix and The Liver

Extracellular Matrix and The Liver : Approach to Gene Therapy

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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches.

The chapters are divided into six sections as follows:

Basic Science of Extracellular Matrix
Cells Responsible for Extracellular Matrix Production
Activation Mechanism of Hepatic Cells and Signal Transduction
Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors
Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases
New Strategies for the treatment of Liver Cirrhosis
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Product details

  • Hardback | 512 pages
  • 163.1 x 234.7 x 29.5mm | 984.3g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Illustrations (some col.)
  • 012525251X
  • 9780125252515

Review quote

"...a good addition to medical, academic and research libraries supporting research and treatment of liver diseases..."
-E-STREAMS (October 2003)
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About Isao Okazaki

Edited by sao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuich and ~Scott I Friedman
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Table of contents

New Insights into the Extracellular Matrix
Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors
Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates
Functions of Proteoglycan/Glycosaminoglycan in Liver
SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology
Cells Responsible for ECM Production in the Liver
Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential
Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair
Molecular Mechanism of Stellate Cell Activation and ECM Remodeling
Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype
Knockout Mice of Matrix Metalloproteinase Genes
Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis
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