Expression Profiling of Human Tumors

Expression Profiling of Human Tumors : Diagnostic and Research Applications

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A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.
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Product details

  • Hardback | 399 pages
  • 184 x 258 x 24mm | 1,161.21g
  • Totowa, NJ, United States
  • English
  • Illustrated
  • 2003 ed.
  • X, 399 p.
  • 1588291227
  • 9781588291226

Back cover copy

Global gene expression profiling is a new and comprehensive approach to the investigation of tumor biology that has the potential to sharply alter the future of cancer research, diagnostic pathology, and clinical oncology. In Expression Profiling of Human Tumors: Diagnostic and Research Applications, over 20 leading investigators offer the first thorough review of the application of this novel technology to human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. For each cancer type, the authors assess the potential of the approach in reaching more precise diagnoses, as well as in the identification of prognostic markers, therapeutic targets, and gene expression patterns that accurately predict therapeutic response. A section on the technology and its novel analytical methods explains both the theory and practice of comprehensive gene expression profiling
Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications provides every cancer researcher, oncologist, pathologist, and cancer surgeon an essential introduction to the most promising high-throughput investigative approach in molecular biology today-a technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.
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Table of contents

Part I. Introduction

Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumors
Marc Ladanyi and William L. Gerald

Part II. Technical Aspects

cDNA Microarrays
Paul S. Meltzer

Oligonucleotide Microarrays
Marina Chicurel and Dennise Dalma-Weiszhausz

Serial Analysis of Gene Expression (SAGE) in Cancer Research
C. Marcelo Aldaz

Tissue Arrays
Cyrus V. Hedvat

Microarray Data Analysis: Cancer Genomics and Molecular Pattern Recognition
Pablo Tamayo and Sridhar Ramaswamy

The Role of Tumor Banking and Related Informatics
Stephen J. Qualman, Jay Bowen, Sandra Brewer-Swartz, and Mary France

Part III. Applications

Characterization of Gene Expression Patterns for Classification of Breast Carcinomas
Irene L. Andrulis, Nalan Gokgoz, and Shelley B. Bull

Microarray Analysis of Colorectal Cancer
Daniel A. Notterman, Carrie J. Shawber, and Wei Liu

Gene Expression Analysis of Prostate Carcinoma
William L. Gerald

Classification of Human Lung Carcinomas by mRNA Expression Profiling
Arindam Bhattacharjee and Matthew Meyerson

Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarrays
Marta Sanchez-Carbayo and Carlos Cordon-Cardo

Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications
Masayuki Takahashi and Bin Tean Teh

Expression Profiling of Pancreatic Ductal Adenocarcinoma
Christine A. Iacobuzio-Donahue and Ralph H. Hruban

Gene Expression in Ovarian Carcinoma
Garret M. Hampton

Classification of Pediatric Tumors Using DNA Microarrays
Javed Khan and Marc Ladanyi

Transcriptomes of Soft Tissue Tumors: Pathologic and Clinical Implications
Sabine C. Linn, Rob B. West, and Matt van de Rijn

Gene Expression Profiling inLymphoid Malignancies
Wing C. Chan and Louis M. Staudt

Gene Expression Profiling of Brain Tumors
Meena K. Tanwar and Eric C. Holland

Expression Profiling of Bone Tumors
Deborah Schofield, Daniel Wai, and Timothy J. Triche

Index
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Review quote

"This timely and topical book provides cancer researchers, oncologists, pathologists and cancer surgeons with an essential introduction to the most promising high-throughput investigative approach in molecular biology today...." (biotech-online.com)


"...written clearly and in great detail with excellent often colorful illustrations which make them very easy to follow and very understandable...a major contribution to the field of expression profiling of human tumors for both these in the fields as well as those wanting to learn about this technique and its applications." (Medical Oncology)
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