Experimental In Vitro Neurotoxicology

Experimental In Vitro Neurotoxicology

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The shift towards the use of tissue culture systems for the study of neurotoxicity is accelerating, driven in part by ethical and legislative pressures against the use of animals. But the major impetus has come from a better understanding of the behaviour and properties of different types of nerve cell "in vitro". Many of the cellular responses to neurotoxicants are retained in culture and valuable mechanistic and predictive information in neurotoxicology can be obtained provided that correct procedures are employed. This book provides an account of the current levels of understanding in this subject and describes the application of "in vitro" systems for use in experimental neurotoxicology. It should be a useful reference for postgraduates and researchers working in toxicology, neuroscience, pathology and related fields.show more

Product details

  • Hardback | 304 pages
  • 169.2 x 249.9 x 19.3mm | 716.69g
  • Taylor & Francis Ltd
  • London, United Kingdom
  • English
  • 0748403884
  • 9780748403882

Table of contents

1. An Introduction to the practical Applications of the New In Vitro Tests O. Flint 2. Structure, Function and Toxicity in Nervous Tissue V. Pentreath 3. Assessment of Toxicant-induced Damage T. Parker and R. Clothier 4. Toxic Cell Damage David Ray5. Endpoints and Mechanisms M. Leist, E. Reffando-May, A. Castoldi and P. Nicotera 6. The Developing In Vitro Neurotoxicology Mark Cookson 7. Functional Biochemical Indicators Mark Cookson 8. Nuclear and Cell Control J. Jiang and J Klaunig 9. Cell Contactand Cell Communication C. Atterwill and W. Purcell 10. Brain Spheroid and Other Organontypic Culture Systems in In Vitro Neurotoxicology B. Veronesi and M. Ehrich 11. Cell Culture Models of Environmental Chemical Neurotoxicity Toward the acceptance of InVitro Neurotoxicity tests M. Balls and E. Walum. Institute, USA, V. Pentreath, University of Salford, UK, T. Parker, University of Nottingham, UK, R. Clothier, University of Nottingham, UK, David Ray, Medical Research Council Toxicology Building, UK, M.Leist, University of Konstanz, Germany, E. Reffando-May, University of Konstanz, Germany, A. Castoldi, University of Konstanz, Germany, P. Nicotera, University of Konstanz, Germany, Mark Cookson, University of Newcastle, UK, J. Jiang, Indiana University,USA, J Klaunig, Indiana University, USA, C. Atterwill, Roche Discovery, Welwyn, UK, W. Purcell, University of the West of England, UK, B. Veronesi, US Environmental Protection Agency, M. Ehrich, Virginia-Maryland Regional College of Veterinary Medicine,USA, M. Balls, JCR Institute for Health and Consumer Protection, Italy, E. Walum, Pharmacia & Upjohn, Sweden.show more

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