Evidence for the Inhibition of Dengue Virus Binding in the Presence of Silver Nanoparticles

Evidence for the Inhibition of Dengue Virus Binding in the Presence of Silver Nanoparticles

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Description

Dengue is an emerging hemorrhagic fever virus and widely considered the most important arbovirus in the world. Dengue virus (DENV) is a positive-sense RNA virus that exists in 4, potentially 5, antigenic serotypes. Currently, no vaccines or treatments are approved for DENV infections. Unsuccessful vaccine trials open the door for non-traditional treatments such as silver nanoparticles. Silver nanoparticles (AgNP) are known to inhibit viral replication of numerous viruses but have never before been tested for inhibition of dengue virus type 2 (DENV2, ATCCA(r) VR-1584a cents). For the first time, this research presents up to a 96% reduction in DENV2 binding to Vero cells following pretreatment with AgNP (6-10nm, 25Aug/mL). These results suggest that similarly to other viruses, DENV2 can be inhibited at the first stage of the virus replication cycle, binding & entry."show more

Product details

  • Paperback | 48 pages
  • 215.9 x 279.4 x 2.79mm | 176.9g
  • Createspace
  • United States
  • English
  • black & white illustrations
  • 1514166992
  • 9781514166994