Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis: Volume 31

Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis: Volume 31 : Part A

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This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis.
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Product details

  • Hardback | 278 pages
  • 154 x 232 x 20mm | 498.95g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0124047408
  • 9780124047402

Table of contents

Biochemistry and Function of RNA Exosomes

Michal Lubas, Aleksander Chlebowski, Andrzej Dziembowski and Torben Heick Jensen

Plant Exosomes and Cofactors
Heike Lange and Dominique Gagliardi

Structure and Activities of the Eukaryotic RNA Exosome
Elizabeth V. Wasmuth and Christopher D. Lima

TRAMP Stimulation of Exosome
Peter Holub and Stepanka Vanacova

XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells

Sarah Geisler and Jeff Coller

Structures of 5'-3' Exoribonucleases (XRNs)
Jeong Ho Chang, Song Xiang and Liang Tong

The Diverse Functions of the Nuclear Rat1/Xrn2 Exonuclease
Michal Krzyszton, Monika Zakrzewska-Placzek, Michal Koper and Joanna Kufel

Normal and Aberrantly Capped mRNA Decapping
Megerditch Kiledjian, Mi Zhou and Xinfu Jiao

Activity and Function of Deadenylases
Christiane Harnisch, Bodo Moritz, Christiane Rammelt, Claudia Temme and Elmar Wahle

The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism

Kevin Roy and Guillaume F. Chanfreau
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About Fuyuhiko Tamanoi

Dr Guillaume Chanfreau obtained his Bachelor Degree from Universite Claude Bernard Lyon and ENS Lyon and his PhD in Microbiology from Universite Paris VI. During his PhD, mentored by Alain Jacquier, he characterized the mechanism of splicing of group II intron ribozymes. Dr Chanfreau then completed postdoctoral training at UCSF with Christine Guthrie, where he identified novel factors involved in 3'-end processing of mRNAs and small RNAs. After this postdoctoral training, he was recruited at UCLA as a professor in the Department of Chemistry and Biochemistry where he teaches a Biochemistry upper division course focused on DNA, RNA and protein synthesis. At UCLA, Dr Chanfreau has developed a research program focused on understanding the mechanisms of RNA degradation and RNA processing, and how these processes contribute to regulate gene expression. Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.
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