Ethnopharmacology of Medicinal Plants
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Ethnopharmacology of Medicinal Plants : Asia and the Pacific

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Description

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: "I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes." Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but "hits" can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.show more

Product details

  • Hardback | 228 pages
  • 184 x 260 x 22mm | 798.34g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • New edition
  • New edition
  • 322 Illustrations, black and white; XII, 228 p. 322 illus.
  • 1588297489
  • 9781588297488

Review quote

From the reviews: "This book contains brief descriptions and evaluations of some active ingredients and the medicinal uses of about 100 plants found in Asia ... . The stated purpose is to show the rich source of potential drugs in the estimated 6,000 plant species in Asia ... . This objective is met ... . A unique feature of the book is the emphasis on similar chemicals found in some plant families ... . Adequate references to the scientific literature are given for each plant." (Stata Norton, Doody's Book Review Service, January, 2007) "This book presents several aspects of the pharmacology, chemistry, botany and folkloric use of selected medicinal plants that can be found in Asia and the Pacific. It is generously illustrated with line drawings for many of the plants under discussion, as well as examples of chemical structures. ... The book is organized into three chapters ... . This book should be of interest to academic, industrial or government scientists with an interest in the potential of the regional flora for drug discovery." (James Graham, Phytomedicine, Vol. 15, 2008)show more

Table of contents

1. Anti-Inflammatory Plants 1.1. General Concept 1.2. Inhibitors of Phospholipase A2 Medicinal Aristolochiaceae Aristolochia indica L. Aristolochia kaempferi Willd. Aristolochia recurvilabra Hance Thottea grandiflora Rottb. Medicinal Myristicaceae Horsfieldia amygdalinia (Wall.) Warb. Horsfieldia valida (Miq.) Warb. Medicinal Caprifoliaceae Lonicera japonica Thunb. Sambucus javanica Reinw. ex Bl. Weigela floribunda (Sieb. & Zucc.) K. Koch. Medicinal Asteraceae Cirsium japonicum DC Crossotephium chinense L. 1.3. Inhibitors of Cyclooxygenase Medicinal Apocynaceae Trachelospermum asiaticum (Sieb. & Zucc.) Nak. Medicinal Clusiaceae Garcinia atroviridis Griff. Medicinal Asteraceae Chrysanthemum sinense Sab. Medicinal Polygonaceae Polygonum amphibium L. Medicinal Lamiaceae Ocimum basilicum L. Glechoma brevituba Kuprian 1.4. Inhibitors of Lipoxygenases Medicinal Myrsinaceae Ardisia villosa Roxb. Medicinal Clusiaceae Hypericum erectum Thunb. Medicinal Asteraceae Medicinal Apiaceae Bupleurum chinense DC 1.5. Inhibitors of Elastase Medicinal Asteraceae Sigesbeckia orientalis L. Sigesbeckia glabrescens Mak Mikania cordata (Burm.f.) B.L. Robinson Medicinal Droseraceae Drosera rotundifolia L. 1.6. Inhibitors of Nitric Oxide Synthetase Medicinal Asteraceae Inula chinensis Rupr. ex Maxim. Carpesium divaricatum Sieb. et Zucc Medicinal Lauraceae Neolitsea zeylanica Nees (Merr.) (Tetradenia Litsea cubeba (Lour.) Pers. Litsea odorifera Val. Medicinal Solanaceae Physalis alkekengi L. 1.7. Conclusion and Future Prospects 1.8. References 2. Plant Affecting the Central Nervous System 2.1. General Concept 2.2. Plants Affecting the Serotoninergic Neurotransmission Medicinal Annonaceae Fissistigma lanuginosum (Hook.f. & Thoms.) Merr. Cyathostemma micranthum (A. DC.) J. Sinclair. Medicinal Myristicaceae Horsfieldia glabra (Bl.) Warb. Medicinal Convolvulaceae Ipomoea obscura (L.) Ker-Gawl. Ipomoea digitata L. Ipomoea indica Merr. Medicinal Apocynaceae Ervatamia pandacaqui (Poir.) Pichon Ervatamia corymbosa (Roxb.) King & Gamble Medicinal Zygophyllaceae Tribulus terrestris L. Medicinal Polygalaceae Polygala tenuifolia Polygala japonica Houtt. Polygala glomerata Lour. Medicinal Rubiaceae Psychotria adenophylla Wall. Rubia cordifolia L. Uncaria rhynchophylla Miq. 2.3. Plants Affecting the GABAergic Neurotransmission Medicinal Valerianaceae Nardostachys chinensis L. Nardostachys jatamansi DC. Patrinia scabiosaefolia Link Medicinal lamiaceae Scutellaria baicalensis Georgi Leonotis nepetifolia R.Br Medicinal Asteraceae Artemisia stelleriana Bess. Medicinal Orchidaceae Gastrodia elata Bl. Acriopsis javanica Reinw. Bulbophyllum vaginatum Reich. f. Calanthe triplicata (Villem.) Ames Calanthe vestita Lindl. Dendrobium crumenatum Sw. 2.4. Plants Interfering with the Glycinergic System Medicinal Loganiaceae Strychnos ignatii Berg. Strychnos minor Dennst. Strychnos axillaris Colebr. Medicinal Apocynaceae 2.5. Plants Affecting the Dopaminergic Neurotransmission Medicinal Araliaceae Acanthopanax gracilistylus W. W. Sm. Acanthopanax trifoliatus (L.) Merr. Acanthopanax ricinifolius Seeman Medicinal Verbenaceae Vitex negundo L. Vitex trifolia L Vitex quinata (Lour.) F.N. Will. Vitex vestita Wallich ex Schauer Medicinal Sapindaceae Erioglossum rubiginosum (Roxb.) Bl. Sapindus mukorossi Gaertn Dodonaea viscosa (L.) Jacq. Medicinal Celastraceae Tripterygium wilfordii Hook f Medicinal Lauraceae Cassytha filiformis L. Cryptocarya griffithiana Wight Medicinal Ranunculaceae Aconitum fischeri Reichb Coptis teeta Wall. Cimicifuga foetida L. Medicinal Menispermaceae Stephania cepharantha Hayata 2.6. Conclusion and Future Prospect 2.7. References 3. Plants for Chemotherapy of Neoplastic Diseases 3.1. General Concept 3.2. Topoisomerase Inhibitors Medicinal Annonaceae Artabotrys suaveolens Bl. Fissistigma fulgens (Hk. f. et Th.) Merr. Friesodielsia latifolia Hk. f. et Th. Medicinal Lauraceae Persea thunbergii (Sieb. & Zucc.) Kosterm. Lindera tzumu Hemsl. Cassytha filiformis L. Medicinal Hernandiaceae Illigera luzonensis L. Medicinal Ebenaceae Diospyros sumatrana Miq. Diospyros toposioides King & Gamble Medicinal Rubiaceae Prismatomeris albiflora Thaw, non King Knoxia valerianoide Thorel Damnacanthus indicus Gaertn. Neonauclea pallida (Reinw. ex Havil.) Bakh f. Morinda officinalis How Medicinal Rutaceae Zanthoxylum ailanthoides Sieb. & Zucc. Zanthoxylum bungei Planch. Zanthoxylum piperitum (L.) DC. Zanthoxylum schinifolium Zieb. & Zucc. Medicinal Euphorbiaceae Alchornea villosa (Benth.) Muell. - Arg. Alchornea rugosa (Lour.) Muell. Arg Phyllanthus acidus (L.) Skeels Macaranga triloba (Reinw.) Muell.-Arg. Medicinal Hamamelidaceae Altingia excelsa Noronha Medicinal Lamiaceae Salvia plebeia R.Br. Salvia japonica Thunb. Salvia miltiorrhiza Bunge 3.3. Apoptosis Medicinal Annonaceae Goniothalamus species Pseudouvaria setosa (King) J. Sinclair Medicinal Asteraceae Elephantopus mollis Kunth Blumea riparia (Bl.) DC. Spilanthes paniculata Wall. ex DC Lactuca indica L. 3.4. Summary and Future Prospects 3.5. Referencesshow more

Review Text

From the reviews: "This book contains brief descriptions and evaluations of some active ingredients and the medicinal uses of about 100 plants found in Asia ... . The stated purpose is to show the rich source of potential drugs in the estimated 6,000 plant species in Asia ... . This objective is met ... . A unique feature of the book is the emphasis on similar chemicals found in some plant families ... . Adequate references to the scientific literature are given for each plant." (Stata Norton, Doody's Book Review Service, January, 2007) "This book presents several aspects of the pharmacology, chemistry, botany and folkloric use of selected medicinal plants that can be found in Asia and the Pacific. It is generously illustrated with line drawings for many of the plants under discussion, as well as examples of chemical structures. ... The book is organized into three chapters ... . This book should be of interest to academic, industrial or government scientists with an interest in the potential of the regional flora for drug discovery." (James Graham, Phytomedicine, Vol. 15, 2008)show more

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