Epinephrine in the Central Nervous System

Epinephrine in the Central Nervous System

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Once thought to be unimportant in central nervous system activity, epinephrine is now known to play a key role in the brain's regulation of blood pressure, cardiovascular function, and other autonomic activities. This book is a comprehensive account of the morphology, genetics, pharmacology, and electrophysiology of epinephrine in the central nervous system, and its effects on behaviour and autonomic function. Students and research workers in neurology, psychiatry, and pharmacology.
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Product details

  • Hardback | 394 pages
  • 177.8 x 256.54 x 27.94mm | 1,020.58g
  • New York, United States
  • English
  • 225 figures, 54 tables
  • 0195042670
  • 9780195042672

Table of contents

HISTORICAL OVERVIEW: J Axelrod: Following the trail of epinephrine from the periphery to the brain; M Vogt: The changing face of research on epinephrine; MORPHOLOGY OF BRAIN EPINEPHRINE SYSTEMS: T Hokfelt and others: Central phenylethanolamine N-methyltransferase-immunoreactive neurons: Distribution, projections, fine structure, ontogeny and coexisting peptides; L F Agnati and others: Morphometric studies of epinephrine and neuropeptide Y (NPY) costoring neurons in the rat brain; J R Unnerstall & M J Kuhar: Mapping the alpha adrenergic receptor in the central nervous system: A guide to structure and function; M Kalia and others: Connectivity and ultrastructure of nonadrenergic and adrenergic neurons in the medulla oblongata; REGULATION AND GENETICS OF ADRENERGIC SYSTEMS: D J Loftus and others: Inheritance of epinephrine formation rates and phenylethanolamine N-methyltransferase structural heterology in inbred rat strains; M J Evinger and others: Molecular basis for the difference in buffalo and Fischer rat PNMT expression; K L Kelner and others: Steroid control of neurotransmitter synthesis: Glucocorticoid regulation of phenylethanolamine N-methyltransferase; J M Saavedra: Brain epinephrine in hypertension and stress; PHARMACOLOGICAL APPROACHES TO ADRENERGIC SYSTEMS: G L Grunewald and others: Approaches to the design of selective inhibitors of phenylethanolamine N-methyltransferase (PNMT): Development of an active site model for PNMT; B Renaud and others: Biochemical pharmacology of brain epinephrine neurons: Comparison with non-epinephrine neurons; L C Terry: Regulation of anterior pituitary hormone secretion by brain epinephrine; H-U Affolter & T Reisine: Epinephrine and CRF stimulate ACTH release and proopiomelanocortin gene expression; M Goldstein and others: Central epinephrine neurons and alpha-2 adrenoceptors; M Fujimoto, E Costa and others: Modulation of epinephrine release from adrenal medulla by gamma-aminobutyric acid; BRAIN AND PERIPHERAL ADRENOCEPTORS: D B Bylund: Subtypes of alpha-2 adrenoceptors in human and rat brain; P A Insel and others: Agonist-regulated metabolism of alpha- and beta-adrenoceptors; D C U'Prichard, D J Loftus & J M Stolk: Functional association between epinephrine neurons and alpha-2 adrenoceptors in discrete brain areas: analysis in inbred rat strains; C A Hamilton, C R Jones, N Deighton & J L Reid: Regulation of brain stem and platelet alpha-2 adrenoceptors; S N Abramson & P B Molinoff: The beta-adrenergic receptor-coupled adenylate cyclase system; S R Childers & S P Baker: Modification of guanine nucleotide actions on receptors and adenylate cyclase; R A Keith, B B Howe & A I Salama: Central and peripheral alpha-2 and beta adrenoceptor changes induced by antidepressant treatments; ADRENERGIC NEURON ELECTROPHYSIOLOGY AND BEHAVIOR: J T Williams, A Surprenant & R A North: Inhibitory synaptic transmission mediated by catecholamines; D N F
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