Eosinophils in Asthma
Eosinophils were placed in a subordinate role in asthma pathogenesis after the suggestion that they nullified certain consequences of mast cell activation. Other factors, reviewed in this book, brought them back into prominence. These include their ability to generate substantial amounts of peptidoleukotrienes and platelet-activating factor, the toxic nature of the constituents of eosinophil granules, and the finding that lymphokines control the proliferation, maturation, and activation of these cells.
- Hardback | 273 pages
- 01 Nov 1989
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
Table of contents
Regulation of eosinophils in man; mast cells and eosinophils (abstract only); control of eosinophil production; immunoglobulin-mediated activation of eosinophils; lipid metabolism by eosinophils; role of eosinophils chemotactic factors on eosinophil activation and leukotriene C4 production; eosinophil heterogeneity; changes in the number of hypodense eosinophils and the expression of complement receptors of eosinophils by allergen inhalation and steroid therapy in patients with brochial asthma; platelet factor ha4 is chemotactic activity for eosinophils and augments Fc and Fc receptor expression on eosinophils; eosinophil biochemistry and killing mechanisms; eosinophils and tissue injury; pharmacological modulation of eosinophil accumulation in guinea pig airways; effects of AH21-132 on bronchial responses of eosinophilic accumulations in the lungs after exposure to the antigen in a guinea pig model of bronchial asthma; allergic inflammation; the eosinophil and asthma; eosinophil lipid mediators and granule secretory products in allergy and asthma.