Endothelium: Volume 77

Endothelium: Volume 77

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Endothelium, the new volume in the Advances in Pharmacology series, presents readers with a variety of chapters that cover various endothelium-derived mediators and their changes with gender, and during vascular development, senescence, and hypertensive disorders.

Topics include endothelium, nitric oxide, gap junctions, potassium channels, endothelin, vascular development, vascular permeability, gender, aging, and preeclampsia. With contributions from the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike.
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Product details

  • Hardback | 462 pages
  • 152 x 229 x 27.94mm | 930g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128043962
  • 9780128043967

Table of contents

The Endothelium-Dependent Nitric Oxide-cGMP Pathway
Fabiola Zakia Monica, Ka Bian and Ferid Murad

Transcriptional and Post Translational Regulation of eNOS in the Endothelium
David J.R. Fulton

Endothelial Small and Intermediate Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Target in Cardiovascular Disease
Ralf Koehler, Aida Olivan-Viguera and Heike Wulff

Epoxyeicosatrienoic Acids and 20-Hydroxyeisosatetraenoic Acid on Endothelial and Vascular Function
John D Imig

Endothelin-1 Biosynthesis, Signaling and Vasoreactivity
Martin Houde, Louisane Desbiens and Pedro D'Orleans-Juste

Endothelium-Dependent Contractions: Prostacyclin and Endothelin-1, Partners in Crime?
Oliver Baretella and Paul M. Vanhoutte

Communication Through Gap Junctions in the Endothelium
Kjestine Schmidt, Rainer Windler and Cor De Wit

Molecular Signaling Pathways Controlling Vascular Tube Morphogenesis and Pericyte Induced Tube Maturation in 3D Extracellular Matrices
Stephanie L.K. Bowers, Pieter R. Norden and George E. Davis

Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells
Michael S. Goligorsky and Karen Hirschi

Estrogens and Coronary Artery Disease: New Clinical Perspectives
Matthias R. Meyer and Matthias Barton

Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia

Jose S. Possomato-Vieira and Raouf A. Khalil
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Review quote

Praise for the Series:
"...recommended not only to pharmacologists but also to all those in related disciplines" --Nature
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About Khalil

Dr. Raouf Khalil is an MD PhD who is very interested in scientific research. After receiving his MD, he joined the graduate school and received his PhD in Pharmacology from the University of Miami, Florida. After doing postdoctoral training at Harvard University, he joined the faculty at University of Mississippi Medical Center. He then moved back to Harvard where he is now Associate Professor at Harvard Medical School and the Brigham and Women's Hospital, Boston, Massachusetts, USA. Dr. Khalil has long been interested in vascular physiology and cell biology. The main focus of his research laboratory is to study the cellular mechanisms of vascular tone under physiological conditions and the changes in these mechanisms in pathological conditions such as coronary artery disease, salt-sensitive hypertension, hypertension in pregnancy, preeclampsia, pulmonary hypertension, and chronic venous disease. State-of-the-art equipment to study various aspects of the vascular system at the whole animal, tissue, cellular, and molecular level are available in his laboratory. Powerful techniques such as physiological bioassays, radioimmunoassays, mRNA and protein analysis, cell and organ culture, immunofluorescence, digital imaging and confocal microscopy are also available. Dr. Khalil's research projects include investigation of endothelium-dependent mechanisms of vascular relaxation, calcium-dependent and calcium-independent mechanisms of vascular and uterine contraction, role of protein kinases and phosphatases in vascular and uterine smooth muscle contraction, mechanisms of sex differences in vascular tone, the role of endothelin in salt-sensitive hypertension, and the role of matrix metalloproteinases in hypertension in pregnancy, preeclampsia, pulmonary hypertension, and chronic venous disease.
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