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Merely three years after the discovery of endothelin, a large amount of information has been generated about the molecular biology, biosynthesis, biological actions and potential physiological and pathological importance of this unique peptide and its isoforms. This first book on endothelins summarizes the early events which lead to the discovery of endothelin, the progress made in understanding the peptide's physiological role, and the current state-of-the-art in contemporaryendothelin research. The book also discusses the potential significance of endothelins in health and disease, covers the potential role of the peptides in the integrated control of the cardiovascular system, and outlines future research directions. This comprehensive monograph is an indispensablereference for basic scientists and clinicians.show more

Product details

  • Hardback | 290 pages
  • 170 x 255 x 23mm | 848g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 0195066413
  • 9780195066418

Table of contents

Tomoh Masaki, Gabor M. Rubanyi: Introduction: The discovery of Endothelin; Paul M. Vanhoutte, Thomas Graser, Thomas F. Luscher: Endothelium-Derived Contracting Factors; Robert F. Highsmith: From Endotensin to Endothelin: The Discovery and Characterization of an Endothelial Cell-Derived Constricting Factor; Penny E. Phillips, Christina Cade, Lynne H. Parker Botelho, Gabor M. Rubanyi: Molecular Biology of Endothelins; Paul W. Erhardt: Endothelin Structure and Structure-Activity Relationships; Hitoshi Miyazaki, Motohiro Kondoh, Yasushi Masuda, Hirotoshi Watanabe, Kazuo Murakami: Endothelin Receptors and Receptor Subtypes; Lynne H. Parker Botelho, Christina Cade, Penny E. Phillips, Gabor M. Rubyani: Tissue Specificity of Endothelin Synthesis and Binding; Tommy A. Brock, N. Raju Danthuluri: Cellular Actions of Endothelin in Vascular Smooth Muscle; Thomas F. Luscher, Chantal Boulanger, Zhihong Yang, Yasuaki Dohi: Interaction between Endothelin and Endothelium-Derived Relaxing Factor(s); Victor J. Dzau, Richard E. Pratt, John P. Cooke: Endothelin as a Growth Factor in Vascular Remodelling and Vascular Disease; Winifred G. Nayler, Xin Hua Gu: Endothelin and the Heart; Andrew J. King, Barry M. Brenner: Renal and Systemic Haemodynamic Actions of Endothelin; Sarah J. Gibson, David R. Springall, Julia M. Polak: Endothelin, a Ubiquitous Peptide: Morphological Demonstration of Immunoreactive and Synthetic Sites and Receptors in the Respiratory Tract and Central Nervous System; Yoshihiko Saito, Kazuwa Nakao, Hiroo Imura: Endothelin in Human Disease. I: Essential Hypertension, Vasospastic Angina, Acute Myocardial Infarction and Chronic Renal Failure; Duncan J. Stewart: Endothelin in Human Disease. II: Shock, Pulmonary Hypertension, and Congestive Heart Failure; Regina Botting & John R. Vane: Endothelin and the Homeostatic Function of the Endothelial Cell; Gabor M. Rubyani, John T. Shepherd: Hypothetical Role of Endothelin in the Control of the Cardiovascular System.show more