Dyneins : Structure, Biology and Disease
Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.
- Hardback | 656 pages
- 187.96 x 236.22 x 38.1mm | 1,678.28g
- 20 Dec 2011
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
About Stephen M. King
Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.
Table of contents
I History and Evolution Chapter 1 Discovery of Dynein and its Properties : A Personal Account Chapter 2 Evolutionary Biology of Dyneins II Structure and Mechanics of Dynein Motors Chapter 3 The AAA+ Powerhouse-Trying to Understand How it Works Chapter 4 Dynein Motor Mechanisms Chapter 5 Structural Analysis of Dynein Intermediate and Light Chains Chapter 6 Biophysics of Dynein In Vivo III Dyneins in Ciliary Biology Chapter 7 Composition and Assembly of Axonemal Dyneins Chapter 8 Organization of Dyneins in the Axoneme Chapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other Organisms Chapter 10 Regulation of Axonemal Outer-Arm Dyneins in Cilia Chapter 11 Control of Axonemal Inner Dynein Arms Chapter 12 Flagellar Motility and the Dynein Regulatory Complex Chapter 13 Regulation of Dynein in Ciliary and Flagellar Movement Chapter 14 Dynein and Intraflagella Transport IV Cytoplasmic Dynein Biology Chapter 15 Cytoplasmic Dynein Function Define by Subunit Composition Chapter 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of Chapter 17 Insights into Cytoplasmic Dynein Function and Regulation from Fungal Genetics Chapter 18 Genetic Insights in to Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in Mouse Chapter 19 Role of Dynactin in Dynein-mediated Motility Chapter 20 Roles of Cytoplasmic Dynein during Mitosis V Dynein Dysfunction and Disease Chapter 21 Does Dynein Influence the Non -Mendelian Inheritance of Chromosome 17 Homologs in Male Mice? Chapter 22 Role of Dynein in Viral Pathogenesis Chapter 23 Cytoplasmic Dynein Dysfunction and Neurodegenerative Disease Chapter 24 Dynein Dysfunction as a Cause of Primary Ciliary Dyskinesia and Other Ciliopathies