Drug-Drug Interactions: Scientific and Regulatory Perspectives: Volume 43 : Scientific and Regulatory Perspectives
- Hardback | 304 pages
- 156 x 228 x 20mm | 621.43g
- 06 Nov 1997
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
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Table of contents
A.P. Li, Preface.
A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions.
F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.
J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.
A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.
A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.
J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.
C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.
G.L. Kedderis, Pharmacokinetics of Drug Interactions.
T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.
J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.
M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.
"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated." --H.E. Kaufmann in CHEMOTHERAPY
"Superb reading material." --JOURNAL OF PHARMACEUTICAL SCIENCES
"This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions." --Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING
About M.W. Anders