Drug Etiology of Agranulocytosis and Aplastic Anemia

Drug Etiology of Agranulocytosis and Aplastic Anemia

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Description

Agranulocytosis and aplastic anaemia figure prominently among certain serious diseases which can be precipitated by drugs. Several hundred different agents with substantially different chemical and pharmacological properties have been implicated, although the evidence incriminating specific drugs has been largely anecdotal. This book describes the findings of a rigorous and comprehensive epidemiological investigation designed to provide reliable quantitative data on the drug aetiology of agranulocytosis and aplastic anaemia. This investigation was a large-scale, population based, case control study. Its objectives were to identify those drugs associated with agranulocytosis and aplastic anaemia, and to estimate incidence rates attributable to specific drugs. In both conceptual and practical terms, this study has broken new ground, by providing the most extensive documentation to date concerning the drug aetiology and incidence of the two dyscrasias.show more

Product details

  • Hardback | 428 pages
  • 165.1 x 244.6 x 39.62mm | 816.46g
  • Oxford University Press Inc
  • New York, United States
  • English
  • numerous figures and tables
  • 0195059832
  • 9780195059830

Table of contents

DRUG INDUCED AGRANULOCYTOSIS AND APLASTIC ANEMIA: GENERAL CONSIDERATIONS: The concept of drug safety; Agranulocytosis and aplastic anemia as drug-induced diseases; Evidence for the drug induction of agranulocytosis; Evidence for the drug induction of aplastic anemia; STRATEGIES FOR OBTAINING INFORMATION ABOUT DRUG EFFECTS: Benefit, risk, the present study; THE DISEASES (by Herman Heimpel): Agranulocytosis, Aplastic anemia; THE DESIGN OF THE STUDY: Objectives, definition of cases, study base, sample size estimates, methodological considerations in the collection of data; METHODS: Definition and ascertainment of cases, selection of controls, data collection, data analysis; THE STUDY EXPERIENCE: Origins of the study, pilot study, changes in the study population, completeness of case ascertainment, definition of onset for cases of agranulocytosis, interim analyses; THE STUDY POPULATION: Agranulocytosis, Aplastic anemia, Controls, Summary; INCIDENCE OF AGRANULOCYTOSIS: The study base: overall incidence, community-acquired agranulocytosis, comments; INCIDENCE OF APLASTIC ANEMIA: The study base: overall incidence, incidence according to various factors, comments; NONNARCOTIC ANALGESIC AND NONSTEROIDAL ANTI-FLAMMATORY DRUGS; The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion; ANTI-INFECTIVE DRUGS: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion; ANTITHYROID DRUGS: The drugs, specific methods, results, summary of results and considerations of validity, comments, conclusion; CARDIOVASCULAR DRUGS AND DIURETICS: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion; PSYCHOTROPIC DRUGS AND ANTIHISTAMINES: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion; MISCELLANEOUS DRUGS: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion; FACTORS OTHER THAN DRUGS: Introduction, specific methods, results, summary of results and consideration of validity, comments, conclusion; GENERAL CONCLUSIONS: Risk estimation for diseases with multiple causes; Etiologically relevant risk intervals; Regional variation of drug-induced agranulocytosis; The strengths and limitations of the present study; Concluding remarks. Appendices; Index of Drug names.show more

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