This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions to provide an unintimidating -- even entertaining -- approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier Drug Interactions Casebook: The Cytochrome P450 System and Beyond and features 29 new cases and updated references throughout. Previous cases have been revised to enhance clarity and the entire book has been reorganized by medical subspecialty -- psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology -- to better facilitate clinical application.
These cases bring the material alive in a way that drier descriptions cannot, offering insight that will improve any practitioner's skills. An introduction to core concepts includes brief reviews of each enzyme system and brings the reader up to speed on how to think about drug-drug interactions. The case vignettes that follow each include a case presentation and a thorough explanation of the mechanism by which the drug interaction(s) occurred. Appendix A details most drug-drug interactions between psychotropic agents and contains metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents, and the remaining appendices detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein.show more