Dopamine and Glutamate in Psychiatric Disorders
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Dopamine and Glutamate in Psychiatric Disorders

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An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.
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Product details

  • Hardback | 600 pages
  • 185.4 x 256.5 x 33mm | 1,224.71g
  • Totowa, NJ, United States
  • English
  • 2005 ed.
  • 57 Illustrations, black and white; XIV, 600 p. 57 illus.
  • 1588293254
  • 9781588293251

Back cover copy

Continous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development.
Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases.
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Table of contents

Part I. Dopamine

Dopamine Receptors
Kim A. Neve

Dopamine Receptor Alternative Splicing
Neil M. Richtand, Laurel M. Pritchard, and Lique M. Coolen

Part II. Glutamate

Glutamatergic Pathways: Their Relevance for Psychiatric Diseases
Yoland Smith

Glutamate Receptors: Ionotropic
Daniel T. Monaghan, Julia C. A. More, Bihua Feng, and David E. Jane

Metabotropic Glutamate Receptors
Krystyna Ossowska

Part III. Schizophrenia

Dopamine and Schizophrenia
Bart A. Ellenbroek

Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis
Stefan Bleich and Johannes Kornhuber

Role of Glycine in Schizophrenia
Beate D. Kretschmer

Part IV. Depression

Dopamine and Depression
Phil Skolnick

Glutamate and Depression
Joaquin Del Rio and Diana Frechilla

Part V. Stress and Aggression

Dopamine, Glutamate, and Aggression
Klaus A. Miczek and Eric W. Fish

Part VI. Anxiety

Glutamatergic Systems and Anxiety
David N. Stephens

Part VII. Attention Deficit Hyperactivity Disorder

Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder
James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, B. J. Casey, Robert Moyzis, David K. Grandy, and Michael I. Posner

Part VIII. Addiction

Dopamine-Glutamate Interactions in Reward-Related Incentive Learning
Richard J. Beninger and Todor V. Gerdjikov

Sensitization and Relapse: Dopamine-Glutamate Interactions
David A. Baker and Peter W. Kalivas

Glutamatergic Neurotransmission in Sensitization
Thomas M. Tzschentke

Glutamatergic Mechanisms of Drug Relapse: Withdrawal and Conditioning Factors
Anton Y. Bespalov and Robert L. Balster

Part IX. Neurodegeneration

Dopamine andNeurodegeneration
Gabriele Gille and Peter Riederer

Glutamate and Neurodegeneration
Antonello Novelli, Marcos Perez-Basterrechea, and Maria Teresa Fernandez-Sanchez

Part X. Parkinson's Disease

Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson's Disease
Heiko Braak and Kelly Del Tredici

Dopamine and Glutamate in Parkinson's Disease: Biochemistry, Clinical Aspects, and Treatment
Heinz Reichmann, Bernd Janetzky, and Peter Riederer

Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson's Disease
Werner J. Schmidt

Part XI. Huntington's Disease

Dopamine and Glutamate in Huntington's Disease
Carlos Cepeda, Marjorie A. Ariano, and Michael S. Levine

Part XII. Dementias

Dopaminergic and Glutamatergic Systems in Alzheimer's Disease
Paul T. Francis

Index
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Review quote

"...offers an excellent review of our understanding of how dopamine and glutamate influence the pathophysiology of psychiatric disease...an impressive effort, and every psychiatrist (and neurologist) should have this book in their reference library." - 4 Stars, Doody's Health Sciences and Book Review Journal
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