Diversity in the Neuronal Machine

Diversity in the Neuronal Machine : Order and Variability in Interneuronal Microcircuits

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This book is a colorful journey into the fascinatingly diverse world of interneurons, an important class of highly heterogeneous cells found in all cortical neuronal networks. Interneurons are known to play key roles in many brain functions, from sensory processing to neuronal oscillations linked to learning and memory. The central aim of the volume is to provide new insights into the striking degree of cellular diversity found in interneuronal microcircuits. The book discusses the history of research into interneuronal variability, the developmental origins of interneuronal diversity, the functional roles of heterogeneity in neuronal circuits, contemporary interneuronal classification systems, and the genetic and homeostatic mechanisms that shape the degree of cell to cell variability within interneuronal populations. It elaborates on new ideas about interneuronal diversity that rest upon theoretical and experimental results, with arguments touching upon evolution, animal behavior, and the mathematical theory of small world networks. This engaging volume is invaluable to neuroscientists and others interested in how neuronal newtworks function; electrical engineers, computational modelers, and physicists interested in neuronal network theory; neurologists and psychiatrists working on mechanisms of neurological and psychiatric disorders; and students and trainees in all of these fields.show more

Product details

  • Hardback | 264 pages
  • 165.1 x 241.3 x 22.9mm | 567g
  • Oxford University Press Inc
  • New York, United States
  • English
  • New.
  • 4 black & white photographs and 47 line illustrations
  • 0195177010
  • 9780195177015

Review quote

"Every so often, a book or monograph comes along whose timing is impeccably linked to the blossoming and maturation of a research field; Diversity in the Neuronal Machine is one such book.this is a book with tremendous depth and critical thinking and in short it is a tremendously satisfying read.I would urge anyone who feels that they have something to say about interneuron classification schemes to read it and carefully consider the arguments set forth."--Chris J. McBain, Laboratory of Cellular and Synaptic Neurophysiology at the National Institute of Child Health and Human Development, in Neuron"Every so often, a book or monograph comes along whose timing is impeccably linked to the blossoming and maturation of a research field; Diversity in the Neuronal Machine is one such book."--Neuron"Dr. Soltesz writes with a clear and entertaining style that keeps the reader's interest throughout."--The Journal of Chemical Neuroanatomyshow more

Table of contents

1. Introduction ; 2. Developmental Origins of Interneuronal Heterogeneity ; 3. Order in Diversity: From Phenomenology to Function ; 4. Cracks in the Crystal: Elusive Neurospecies and the Great Correlation Hunt ; 5. Functions of Heterogeneity: Meaning of Means and Variability of Variances ; 6. Interneuronal Variability: Plasticity and Regulation ; 7. Diversity Beyond Variance ; 8. Fifty Ways to be a Basket Cell: Self-tuning Interneurons with Multiple Solutions for their Tasks ; 9. Interneuronal Diversity and Small World Neuronal Networks ; 10. Closing Thoughts: The Structure of Cortical Microcircuit Theoryshow more

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