Diversity and Functions of GABA Receptors: A Tribute to Hanns Moehler, Part B: Volume 73

Diversity and Functions of GABA Receptors: A Tribute to Hanns Moehler, Part B: Volume 73

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Diversity and Functions of GABA Receptors: A Tribute to Hanns Moehler, Part B, a new volume of Advances in Pharmacology, presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years, which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development.
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Product details

  • Hardback | 284 pages
  • 156 x 234 x 18mm | 599.99g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128026588
  • 9780128026588

Table of contents

1. Reflections on more than 30 years Association with Hanns
Norman G. Bowery
2. Significance of GABAA Receptor Heterogeneity: Clues from Developing Neurons
Jean-Marc Fritschy
3. Regulation of Cell Surface GABAB Receptors: Contribution to Synaptic Plasticity in Neurological Diseases
Dietmar Benke, Karthik Balakrishnan and Khaled Zemoura
4. Restoring the Spinal Pain Gate: GABAA Receptors as Targets for Novel Analgesics
Hanns Ulrich Zeilhofer, William T. Ralvenius and Mario A. Acuna
5. GABAergic Control of Depression-related Brain States
Bernhard Luscher and Thomas Fuchs
6. Mechanisms of Fast Desensitization of GABAB Receptor-Gated Currents
Adi Raveh, Rostislav Turecek and Bernhard Bettler
7. Allosteric Ligands and their Binding Sites Define ï §-Aminobutyric acid (GABA) Type A Receptor Subtypes
Richard W. Olsen
8. Diversity in GABAergic Signaling
Kaspar Vogt
9. The Diversity of GABAA Receptor Subunit Distribution in the Normal and Huntington's Disease Human Brain
HJ Waldvogel and RLM Faull
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About Uwe Rudolph

Dr. Rudolph is Director of the Laboratory of Genetic Neuropharmacoloy at McLean Hospital and Professor of Psychiatry at Harvard Medical School. He studied medicine and completed a research thesis on G proteins at the Freie Universitat Berlin, Germany. After postdoctoral training at Baylor College of Medicine in Houston, Texas, where he developed a mouse model of inflammatory bowel disease and colon cancer, he moved to the Institute of Pharmacology and Toxicology of the University of Zurich to work on GABAA receptors. There, he developed different lines of knock-in mice in which diazepam-sensitive GABAA receptor subtypes were rendered insensitive to diazepam by a histidine to arginine point mutation. Studying these mice enables researchers to uncover unique functional roles of GABAA receptor subtypes. In 2005, he joined McLean Hospital in Belmont, MA, and Harvard Medical School, where his research group is elucidating the functions of GABAA receptor subtypes in defined neuronal populations.
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