List of Principal Authors. Preface. Section I: Morphology, Histopathology and Oncology. 1. Proliferation and Ductal Morphogenesis of Bile Duct Epithelial Cells; A.E. Sirica, et al. 2. Bile Duct Histopathology in Liver Diseases; V.J. Desmet, et al. 3. Stem Cell Biology and Bile Ducts; S.S. Thorgeirsson. 4. Cholangiocarcinoma - Clinical Aspects; K. Okuda. Section II: Physiology and Molecular Biology of Bile Formation and Cholestatic Liver Diseases. 5. Cholangiocyte physiology - Role in Bile Formation; J.G. Fitz. 6. Cholangiocyte Dysfunction, Role in Cholestasis; M. Strazzabosco, et al. 7. Dysregulation of Cholangiocyte Apoptosis by Cytokines; T. Patel. 8. MDR3 Deficiency and Progressive Familial Intrahepatic Cholestasis; E. Jacquemin, et al. 9. Clinical Spectrum of Liver Disease in CFTR Deficiency and Cystic Fibrosis; C. Colombo. 10. Cholestasis in Systemic Infection; M. Trauner, et al. Section III: Cholestatic Liver Disesases - Autoimmunity. 11. Aetiopathogenesis and Clinical Spectrum of Primary Biliary Cirrhosis; R.W. Chapman. 12. Pathogenesis and Clinical Spectrum of Primary Sclerosing Cholangitis; U. Beuers, G. Paumgartner. 13. Immunopathogenesis of Primary Biliary Cirrhosis: Contemporary Issues; L. Dubel, et al. 14. Structural Features of Bile Ducts in Cholestatic Liver Diseases; A.M. Jezequel, et al. Section IV: Cholestatic Liver Diseases - Drugs, Toxins, Fibrosis and Gallstones. 15. Drug and Toxin Induced Vanishing Bile Duct Disorders; A.P. Geubel, C. Sempoux. 16. Fibrosis and Bile Duct Injury; S.L. Friedman. 17. The Pathogenesis of Gallstone Disease; Z. Mare ek, et al. Section V: From Genetics to Endoscopy. 18. Progressive Familial Intrahepatic Cholestasis; P.L.M. Jansen, M. Muller. 19. Magnetic Resonance Cholangiography in Diseases of the Bile Ducts; N. Holzknecht, M. Reiser. 20. Endoscopic Ultrasonography of the Biliary System; T. Roesch. 21. Serological Tests in Cholestatic Liver Disorders: PSC, PBC, and Autoimmune Cholangiopathy; C.P. Strassburg, M.P. Manns. Section VI: Chronic Cholestatic Liver Diseases. 22. The Treatment of PBC and other Vanishing Bile Duct Syndromes; J. Heathcote. 23. Management of Patients with Primary Sclerosing Cholangitis: Medical, Interventional; A. Stiehl, et al. 24. Therapeutic Approaches to Complications of Cholestasis; U. Leuschner. 25. Liver Transplantation in Patients with Chronic Cholestatic Liver Diseases Approaches to Detection of Rejection and its Treatment; M. Hertl, et al. Section VII: Bile Duct Disorders and Gallstone Disease. 26. Biliary Complications after Liver Transplantation: Diagnosis and Management; J. Spi ak. 28. Treatment of Gallstone Disease; S.M. Strasberg. Index.