Diagnostic Molecular Pathology

Diagnostic Molecular Pathology : A Guide to Applied Molecular Testing

5 (1 rating by Goodreads)

Free delivery worldwide

Available. Dispatched from the UK in 2 business days
When will my order arrive?

Description

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described.

The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests.

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions.
show more

Product details

  • Hardback | 582 pages
  • 216 x 276 x 35.56mm | 1,700g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128008865
  • 9780128008867
  • 1,150,292

Table of contents

Section I: Introduction to Molecular Testing

Chapter 1. Basic Concepts in Molecular Pathology-Introduction to Molecular Testing in Human Disease

Chapter 2. Laboratory Approaches in Molecular Pathology-The Polymerase Chain Reaction

Chapter 3. Next-Generation Sequencing in the Clinical Laboratory

Chapter 4. Automation of the Molecular Diagnostic Laboratory

Section II: Molecular Testing in Infectious Disease

Chapter 5. Molecular Testing for Human Imunodeficiency Virus

Chapter 6. Molecular Testing in Hepatitis Virus Related Disease

Chapter 7. Molecular Testing for Human Papillomaviruses

Chapter 8. Molecular Testing for Herpes Viruses

Chapter 9. Molecular Testing for Parvoviruses

Chapter 10. Molecular Testing for Polyomaviruses

Chapter 11. Molecular Testing for Respiratory Viruses

Chapter 12. Molecular Testing for Diseases Associated with Bacterial Infections

Chapter 13. Agents Associated with Sexually Transmitted Infections

Chapter 14. Molecular Methods for Healthcare-Acquired Infections

Chapter 15. Molecular Testing in Emerging Infectious Diseases

Section III: Molecular Testing in Genetic Disease

Chapter 16. Noninvasive Prenatal Screening (NIPS) for Fetal Aneuploidies

Chapter 17. Molecular Testing in Inherited Cardiomyopathies

Chapter 18. Molecular Diagnostics for Coagulopathies

Chapter 19. Molecular Diagnosis of Cystic Fibrosis

Chapter 20. Molecular Testing in Hemochromatosis

Section IV: Molecular Testing in Oncology

Chapter 21. Molecular Testing in Breast Cancer

Chapter 22. Molecular Pathology of Prostate Cancer

Chapter 23. Molecular Testing in Lung Cancer

Chapter 24. Molecular Testing in Colorectal Cancer

Chapter 25. Molecular Pathology and Testing in Melanocytic Tumors

Chapter 26. Molecular Testing for Glioblastoma

Chapter 27. Molecular Testing in Pancreatic Cancer

Chapter 28. Molecular Testing in Gynecologic Cancer

Chapter 29. The Emerging Genetic Landscape in Renal Cell Carcinoma

Chapter 30. Molecular Testing in Thyroid Cancer

Chapter 31. Molecular Testing in Pediatric Cancers

Section V: Molecular Testing in Hematopathology

Chapter 32. Molecular Testing in Chronic Myelogenous Leukemia

Chapter 33. Molecular Testing in Acute Myeloid Leukemia

Chapter 34. Molecular Testing in Myeloproliferative Neoplasms

Chapter 35. Molecular Testing in the Assessment of Bone Marrow Transplant Engraftment

Section VI: Molecular Testing in Personalized Medicine

Chapter 36. Personalized Medicine in Cardiovascular Disease

Chapter 37. Personalized Medicine for Coagulopathies

Chapter 38. Personalized Medicine for Hepatitis C Virus

Chapter 39. Personalized Medicine in Cancer Treatment

Section VII: The Future of Molecular Testing

Chapter 40. Imaging Mass Spectrometry in Clinical Pathology

Chapter 41. Whole Genome Sequencing in the Molecular Pathology Laboratory
show more

Review Text

" Diagnostic Molecular Pathology is destined to become an important cornerstone and go-to volume for pathologists, researchers, and clinicians-indeed anyone who wants to understand the approach and application of modern molecular techniques in disease detection and diagnosis. Drs. Coleman and Tsongalis-and their impressive stable of contributors-are to be congratulated for making the exciting and rapidly expanding science of molecular diagnosis accessible to the novice, while also providing the expert with important details on the nuances. Beyond just a compendium of useful information, it is a well-curated journey through basic concepts, infectious diseases, malignancy, hematopathology, and genetic diseases-and even includes access to a website with lab test videos and decision-making exercises." --Richard N. Mitchell, MD, PhD (Brigham and Women's Hospital and Harvard Medical School)

"With much fanfare, molecular techniques have revolutionized clinical medicine, from diagnosis to personalized medical therapeutics. It is with this background that Diagnostic Molecular Pathology approaches the daunting task of summarizing the advances in the field from infectious disease, heritable and acquired genetic diseases, hematological malignancies, to pharmacogenomics. In a comprehensive publication, the editors perform a yeoman's effort in covering this dynamic and exciting field." --Lawrence M. Silverman, PhD (University of Virginia School of Medicine)

"Diagnostic Molecular Pathology provides a panoramic view of diagnostic molecular pathology testing, written by leaders in the field. It is a great reference and learning tool." --Dani S. Zander, MD (University of Cincinnati Medical Center)
show more

Review quote

"Diagnostic Molecular Pathology is destined to become an important cornerstone and go-to volume for pathologists, researchers, and clinicians-indeed anyone who wants to understand the approach and application of modern molecular techniques in disease detection and diagnosis. Drs. Coleman and Tsongalis-and their impressive stable of contributors-are to be congratulated for making the exciting and rapidly expanding science of molecular diagnosis accessible to the novice, while also providing the expert with important details on the nuances. Beyond just a compendium of useful information, it is a well-curated journey through basic concepts, infectious diseases, malignancy, hematopathology, and genetic diseases-and even includes access to a website with lab test videos and decision-making exercises." --Richard N. Mitchell, MD, PhD (Brigham and Women's Hospital and Harvard Medical School)

"With much fanfare, molecular techniques have revolutionized clinical medicine, from diagnosis to personalized medical therapeutics. It is with this background that Diagnostic Molecular Pathology approaches the daunting task of summarizing the advances in the field from infectious disease, heritable and acquired genetic diseases, hematological malignancies, to pharmacogenomics. In a comprehensive publication, the editors perform a yeoman's effort in covering this dynamic and exciting field." --Lawrence M. Silverman, PhD (University of Virginia School of Medicine)

"Diagnostic Molecular Pathology provides a panoramic view of diagnostic molecular pathology testing, written by leaders in the field. It is a great reference and learning tool." --Dani S. Zander, MD (University of Cincinnati Medical Center)
show more

About Gregory J. Tsongalis

William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman's major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Dr. Tsongalis's research interests are in the pathogenesis of solid tumors, disease association of SNP genotyping and personalized medicine. He has authored/edited eight textbooks in the field of molecular pathology, published more than 170 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. Dr. Tsongalis has been the recipient of numerous investigator/scientist awards. He is on the editorial board of 9 journals including Clinical Chemistry, the Journal of Molecular Diagnostics and Clinical Chemistry and Laboratory Medicine.
show more

Rating details

1 ratings
5 out of 5 stars
5 100% (1)
4 0% (0)
3 0% (0)
2 0% (0)
1 0% (0)
Book ratings by Goodreads
Goodreads is the world's largest site for readers with over 50 million reviews. We're featuring millions of their reader ratings on our book pages to help you find your new favourite book. Close X