Deoxyribonucleic Acid Topoisomerases in Cancer

Deoxyribonucleic Acid Topoisomerases in Cancer

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Oncologists, clinical and molecular pharmacologists; cell more

Product details

  • Hardback | 331 pages
  • 150 x 230 x 24mm | 799g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 0195061063
  • 9780195061062

Table of contents

PART I: GENETICS AND BIOLOGY OF DNA TOPOISOMERASES: Genetic and biochemical studies of eukaryotic DNA topoisomerases - from yeast to man; DNA topoisomerases and antitumor drugs; DNA topoisomerase genes; The influence of camptothecin on topoisomerase I interaction with genomic sequences; PART II: INHIBITORS OF TOPOISOMERASE I: Chemistry and antitumor activity of camptothecins; Structure-activity relationship of camptothecins; Cellular regulation and chromatin localization of topoisomerase I action; Evidence for topoisomerase heterogeneity: Implications for the discovery of novel antitumor drugs; Biochemistry of camptothecin - topoisomerase I interaction; PART III: INHIBITORS OF TOPOISOMERASE II: A unifying model for topoisomerase inhibition by epipodophyllotoxins and intercalating agents; Effects of etoposide on topoisomerase II-mediated reactions: Analysis of drug action; Role of the T4 topoisomerase in sensitivity and resistance to m-AMSA; Models of DNA recombination: potential role of topoisomerases; PART IV: DRUG RESISTANCE AND TOPOISOMERASE II: Reconstitution of topoisomerase II-mediated drug sensitivity in somatic cell hybrids; Atypical multi-drug resistance; Utility of topoisomerase inhibitors in clinical oncology; Layers of drug resistance in cancer: is topoisomerase II one of them?show more