DNA Topoisomerases: Topoisomerase-Targeting Drugs: Volume 29B

DNA Topoisomerases: Topoisomerase-Targeting Drugs: Volume 29B

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Description

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
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Product details

  • Hardback | 315 pages
  • 150 x 228 x 22mm | 639.58g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0120329301
  • 9780120329304

Table of contents

F.M. Muggia and H.A. Burris, Clinical Development of Topoisomerase-Interactive Drugs.
D. Peereboom, M. Charron, and S.H. Kaufmann, Topoisomerases in Human Leukemia.
D. Costin and M. Potmesil, Preclinical and Clinical Development of Camptothecins.
Y. Pommier, A. Tanizawa, and K.W. Kohn, Mechanisms of Topoisomerase I Inhibition by Anticancer Drugs.
T. Andoh and K. Okada, Drug Resistance Mechanisms of Topoisomerase I Drugs.
N. Osheroff, A.H. Corbett, and M.J. Robinson, Mechanism of Action of Topoisomerase II-Targeted Antineoplastic Drugs.
P. Darpa, Determinants of Sensitivity to Topoisomerase-Targeting Antihumor Drugs.
W.T. Beck, M.K. Danks, J.S. Wolverton, M. Chen, B. Granzen, R. Kim,and D.P. Suttle, Resistance of Mammalian Tumor Cells to Inhibitors of DNA Topoisomerase II.
K.N. Kreuzer, A Bacteriophage Model System for Studying Topoisomerase Inhibitors.
T.A. Shapiro, Drugs Affecting Trypanosome Topoisomerases.
J.L.Nitiss, Yeast as a Genetic Model System for Studying Topoisomerase Inhibitors.
L.L. Shen and J.M. Fostel, DNA Topoisomerase Inhibitors as Antifungal Agents.
A.Y. Chen and L.F. Liu, Design of Topoisomerase Inhibitors to Overcome MDR1-Mediated Drug Resistance. Appendices:
J.C. Wang, An Introduction to DNA Supercoiling and DNA Topoisomerase-Catalyzed Linking Number Changes of Supercoiled DNA.
P.R. Caron and J.C. Wang, Alignment of Primary Sequences of DNA Topoisomerases.
References.
Subject Index.
Contents of Previous Volumes.
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Review quote

Praise for the Serial
"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading."
--JOURNAL OF PHARMACEUTICAL SCIENCES
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About J. Thomas August

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children. Leroy F. Liu serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.
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