DNA Repair Enzymes: Cell, Molecular, and Chemical Biology: Volume 591

DNA Repair Enzymes: Cell, Molecular, and Chemical Biology: Volume 591

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DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA repair enzymes. Topics in this new release include chapters on the Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells, the Proteomic Analyses of the Eukaryotic Replication Machinery, DNA Fiber Analysis: Mind the Gap!, Comet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single Cells, Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner, Base Excision Repair Variants in Cancer, and Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli.show more

Product details

  • Hardback | 478 pages
  • 152 x 229 x 30.48mm | 930g
  • Elsevier Science Publishing Co Inc
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128118466
  • 9780128118467

Table of contents

Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension CellsNathaniel E. Wiest and Alan E. TomkinsonProteomic Analyses of the Eukaryotic Replication MachineryDavid CortezDNA Fiber Analysis: Mind the Gap!Annabel Quinet, Denisse Carvajal-Maldonado, Delphine Lemacon and Alessandro VindigniComet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single CellsManas Mondal and Jia GuoExamining DNA Double-Strand Break Repair in a Cell Cycle-Dependent MannerJanapriya Saha, Shih-Ya Wang and Anthony J. DavisBase Excision Repair Variants in CancerCarolyn G. Marsden, Julie A. Dragon, Susan S. Wallace and Joann B. SweasyFluorescence-Based Reporters for Detection of Mutagenesis in E. coliMelissa Standley, Jennifer Allen, Layla Cervantes, Joshua Lilly and Manel CampsSequencing DNA for the Oxidatively Modified Base 8-Oxo-7,8-DihydroguanineAaron M. Fleming, Yun Ding and Cynthia J. BurrowsXenopus laevis as Model System to Study DNA Damage Response and Replication Fork StabilityVincenzo Sannino, Federica Pezzimenti, Stefania Bertora and Vincenzo CostanzoEnsemble and Single-Molecule Analysis of NHEJ in Frog Egg ExtractsThomas Graham, Johannes C. Walter and Joseph J. LoparoAnalysis of Structure-Selective Endonuclease Activities From Yeast and Human ExtractsJoao Matos and Stephen C. WestStrategies and Methods of Transcription-Coupled Repair Studies In Vitro and In Vivo Vitaly Epshtein, Venu Kamarthapu and Evgeny NudlerReconstituted System for the Examination of Repair DNA Synthesis in Homologous RecombinationYoungho Kwon, James M. Daley and Patrick SungCurrent and Emerging Assays for Studying the Primer Synthesis Activities of DNA PrimasesThomas A. Guilliam and Aidan J. DohertyElectrical Probes of DNA-Binding ProteinsJacqueline K. Barton, Phillip L. Bartels, Yingxin Deng and Elizabeth O'BrienPreparation of Stable Nitrogen Mustard DNA Interstrand Cross-Link Analogs for Biochemical and Cell Biological StudiesAlejandra Castano, Upasana Roy and Orlando D. Scharershow more

About Brandt Eichman

Dr. Eichman is a Professor of Biological Sciences and Biochemistry at Vanderbilt University, where his laboratory investigates the structural mechanisms of protein machines involved in maintenance of genome integrity. Professor Eichman was initially trained as a synthetic organic chemist at the University of Mississippi (B.S., Chemistry, 1993). He received his Ph.D. in Biochemistry and Biophysics in 2000 from Oregon State University, where he used X-ray crystallography to study the effects of crosslinking agents on DNA structure and determined the landmark structure of the Holliday junction, the four-stranded DNA intermediate formed during genetic recombination. As an NIH postdoctoral fellow from 2000-2004 with Tom Ellenberger at Harvard Medical School, Eichman studied the structural enzymology of DNA repair and replication proteins. Current projects in the Eichman lab focus on base excision repair of DNA alkylation damage and restart of stalled replication forks during the DNA damage response. Dr. Eichman holds the 2009 Young Investigator Award from the Sigma Xi Scientific Research Society, the Vanderbilt Chancellor's Award for Research, two Vanderbilt-Ingram Cancer Center Impact Awards, and in 2013 became a member of the Faculty of 1000. Eichman teaches introductory and advanced undergraduate biochemistry and serves as the co-Director of the Vanderbilt Undergraduate Program in Biochemistry and Chemical Biology.show more