DNA Cleavage by Enediyne Molecules. Enediynes as Probes of Nucleic Acid Structure; I.H. Goldberg, et al. The Intrinsic Flexibility and Drug-Induced Bending of Calicheamicin DNA Targets; A. Salzberg, et al. Recent Biophysical and Biological Studies on the Mechanism of Action of Calicheamicin; G. Krishnamurthy, et al. Kedarcidin and Maduropeptin, Two Novel Chromoproteins with Potent Antitumor Activities; N. Zein. Dynemicin A, a Novel Enediyne DNA Cutter; Y. Sugiura, T. Kusakabe. Bleomycin: the Paradigm of DNA Cleavers Based on Metal Complexes. Polynucleotide Cleavage and the Expression of Antitumor Activity by Bleomycin; S.M. Hecht. Bleomycin Reaction Pathways: Kinetic Approaches; R.M. Burger, K. Drlica. Selected Generation and Cleavage of C4'-Modified Oligonucleotides; B. Giese. Site-Specific DNA Cleavage. Site Specific Oxidative Scission of Nucleic Acids and Proteins; D.S. Sigman. Sequence Selective DNA Cleavage by PNA-NTA Conjugates; J. Lohse, et al. The Synthesis and DNA/RNA Hybridization Properties of DNG, a Putative Antisense Agent with an Attractive Polycationic Guanidinium Backbone; R.O. Dempcy, T.C. Bruice. Design of Photoactivatable DNA-Cleaving Amino Acids with High Sequence Selectivity; I. Saito, et al. Rational Design of a New Class of DNA Cleaver Based on Prediction of Minor Groove Binding Interactions and NMR Structural Studies; A. Wilton, et al. Binary Systems of Oligonucleotide Conjugates for Sequence Specific Energy-Transfer Sensitized Photomodification of Nucleic Acids; V.V. Vlassov, et al. Mechanism of Oxidative DNA Cleavage. Targeted Oxidative DNA Cleavage Mediated by Oligonucleotide-Cationic Metalloporphyrin Conjugates; J. Bernadou, et al. Pulse Radiolysis and Laser PhotolysisStudies on Nucleotide Radicals. The Protonation State of the Radicals; S. Steenken. Redox Regulation of the Human Immunodeficiency Virus Type 1 (HIV-1); J. Piette. RNA Cleavage by RNase H. Ribonuclease H: from Enzymes to Antisense Effects of Oligonucleotides; J.J. Toulme et al. Hydrolysis of RNA by ribozymes and metal complexes. Structure, Activity and Application of Chemically Modified Hammerhead Ribozymes; F. Eckstein. The Hairpin Ribozyme; J.A. Grasby. Sequence- Specific Cleavage of RNA Using Lanthanide Complexes Linked to Oligonucleotides; R. Haner, et al. Synergism of Two Metal Ions for the Hydrolysis of DNA and RNA; M. Komiyama, et al. Texaphyrin-Based Nuclease Analogues. Rationally Designed Approaches to the Catalytic Cleavage of RNA and DNA Targets; D. Magda, et al. Ribozyme Mimics for Catalytic Antisense Strategies; J.K. Bashkin, et al. Subject Index.